Literature DB >> 21534540

Tigliane-type diterpenoid glycosides from Euphorbia fischeriana.

Li-Li Pan1, Ping-Lei Fang, Xing-Jie Zhang, Wei Ni, Lei Li, Liu-Meng Yang, Chang-Xiang Chen, Yong-Tang Zheng, Chang-Tian Li, Xiao-Jiang Hao, Hai-Yang Liu.   

Abstract

Investigation of whole plants of Euphorbia fischeriana afforded three new tigliane-diterpenoid glycosides, fischerosides A-C (1-3), together with 11 known diterpenoids. Fischerosides A-C (1-3) are the first tigliane-type diterpenoid glucosides. Their structures were determined by a combination of 1D and 2D NMR, MS, and acid hydrolysis. Inhibitory activity against HIV-1 was assessed for compounds 1-5. The new compound 3 showed an EC₅₀ value of 0.02 μM and a therapeutic index (TI) of 17.50, while prostratin (4) and 12-deoxyphorbol-13,20-diacetate (5) showed significantly greater anti-HIV-1 activity.

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Year:  2011        PMID： 21534540     DOI： 10.1021/np200058c

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

1.  Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity.

Authors:  Cheng Jiang; Pan Luo; Yu Zhao; Jialing Hong; Susan L Morris-Natschke; Jun Xu; Chin-Ho Chen; Kuo-Hsiung Lee; Qiong Gu
Journal:  J Nat Prod       Date:  2016-01-12       Impact factor: 4.050

2.  Anti-HIV tigliane diterpenoids from Reutealis trisperma.

Authors:  Yan Lu; Ya-Si Huang; Chin-Ho Chen; Toshiyuki Akiyama; Susan L Morris-Natschke; Yung-Yi Cheng; Ih-Sheng Chen; Sheng-Zehn Yang; Dao-Feng Chen; Kuo-Hsiung Lee
Journal:  Phytochemistry       Date:  2020-03-28       Impact factor: 4.072

3.  A reduction of viral mRNA, proteins and induction of altered morphogenesis reveals the anti-HTLV-1 activity of the labdane-diterpene myriadenolide in vitro.

Authors:  Camila Pacheco Silveira Martins; Orlando Abreu Gomes; Marina Lobato Martins; Luciana Debortoli de Carvalho; Jaqueline Gontijo de Souza; Flavio Guimaraes Da Fonseca; Rodrigo Gonçalves Silva dos Santos; Margareth Spangler Andrade; Carlos Leomar Zani; Elaine Maria de Souza-Fagundes; Edel Figueiredo Barbosa-Stancioli
Journal:  BMC Microbiol       Date:  2014-12-24       Impact factor: 3.605

Review 4.  Structural Diversity and Biological Activities of Diterpenoids Derived from Euphorbia fischeriana Steud.

Authors:  Baiyu Jian; Hao Zhang; Jicheng Liu
Journal:  Molecules       Date:  2018-04-18       Impact factor: 4.411

5.  Stainless Steel Wire Mesh Supported Molecularly Imprinted Composite Membranes for Selective Separation of Ebracteolata Compound B from Euphorbia fischeriana.

Authors:  Yukun Ma; Haijun Wang; Mengyan Guo
Journal:  Molecules       Date:  2019-02-04       Impact factor: 4.411

6.  Three new ent-abietane diterpenoids from the roots of Euphorbia fischeriana and their cytotoxicity in human tumor cell lines.

Authors:  Minghui Li; Fang He; Yuan Zhou; Meigui Wang; Pingde Tao; Qingmei Tu; Guanghui Lv; Xintao Chen
Journal:  Arch Pharm Res       Date:  2019-04-17       Impact factor: 4.946

Review 7.  Phytochemistry and Pharmacological Activities of the Diterpenoids from the Genus Daphne.

Authors:  Yi-Wen Nie; Yuan Li; Lan Luo; Chun-Yan Zhang; Wei Fan; Wei-Ying Gu; Kou-Rong Shi; Xiao-Xiang Zhai; Jian-Yong Zhu
Journal:  Molecules       Date:  2021-10-31       Impact factor: 4.411

8.  Development of a Matrix Solid-Phase Dispersion Extraction Combined with UPLC/Q-TOF-MS for Determination of Phenolics and Terpenoids from the Euphorbia fischeriana.

Authors:  Wenjing Li; Yu Lin; Yuchun Wang; Bo Hong
Journal:  Molecules       Date:  2017-09-11       Impact factor: 4.411
  8 in total

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