Literature DB >> 21534039

Synthesis and antitumor activity of novel podophyllotoxin derivatives against multidrug-resistant cancer cells.

Yong-En Guo1, Hong Chen, Song Zuo, Dai-Lin Liu, Yan-Ling Lu, Jing-Jing Lv, Shao-Peng Wen, Tong-Cun Zhang.   

Abstract

Seven novel 4β-N-substituted podophyllotoxin derivatives with indole rings were prepared and evaluated for cytotoxicity against human cancer cell lines HeLa, KB, KBV, K562, and K562/AO2. Most of them demonstrated improved antitumor activity and weak multidrug resistance compared to the drugs currently available.

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Year:  2011        PMID： 21534039     DOI： 10.1080/10286020.2011.568941

Source DB:  PubMed          Journal:  J Asian Nat Prod Res        ISSN： 1028-6020            Impact factor:   1.569


  2 in total

Review 1.  Recent progress on C-4-modified podophyllotoxin analogs as potent antitumor agents.

Authors:  Ying-Qian Liu; Jing Tian; Keduo Qian; Xiao-Bo Zhao; Susan L Morris-Natschke; Liu Yang; Xiang Nan; Xuan Tian; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2014-05-14       Impact factor: 12.944

2.  The efficacy of 2-nitrovinylfuran derivatives against Leishmania in vitro and in vivo.

Authors:  Sergio Sifontes-Rodríguez; Lianet Monzote-Fidalgo; Nilo Castañedo-Cancio; Ana Margarita Montalvo-Álvarez; Yamilé López-Hernández; Niurka Mollineda Diogo; Juan Francisco Infante-Bourzac; Oliver Pérez-Martín; Alfredo Meneses-Marcel; José Antonio Escario García-Trevijano; Miguel Ángel Cabrera-Pérez
Journal:  Mem Inst Oswaldo Cruz       Date:  2015-03-24       Impact factor: 2.743
  2 in total

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