Literature DB >> 21533548

Identification of proteins differentially expressed in gastric cancer cells with high metastatic potential for invasion to lymph nodes.

Do Hee Lee1, Youra Lee, Joohyun Ryu, Sung Goo Park, Sayeon Cho, Je-Jung Lee, Chan Choi, Byoung Chul Park.   

Abstract

In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, urokinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.

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Year:  2011        PMID： 21533548      PMCID： PMC3887625          DOI： 10.1007/s10059-011-1053-z

Source DB:  PubMed          Journal:  Mol Cells        ISSN： 1016-8478            Impact factor:   5.034


  30 in total

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  7 in total

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