PURPOSE OF REVIEW: This review focuses on recent research that explores the role of infectious organisms in the development of autoimmunity and rheumatoid arthritis (RA). RECENT FINDINGS: Human and animal studies provide further evidence supporting a role for the periodontal pathogen, Porphyromonas gingivalis, in the development of RA. The microbiome plays a key role in the developing immune system. Alterations in the bowel microbiome lead to altered innate and adaptive immune responses potentially relevant to the development or persistence of RA. SUMMARY: Microbes and the host response to microbes are important factors in the maintenance of health. Abnormalities or imbalances in these responses can lead to the development of autoimmune inflammatory conditions such as RA.
PURPOSE OF REVIEW: This review focuses on recent research that explores the role of infectious organisms in the development of autoimmunity and rheumatoid arthritis (RA). RECENT FINDINGS:Human and animal studies provide further evidence supporting a role for the periodontal pathogen, Porphyromonas gingivalis, in the development of RA. The microbiome plays a key role in the developing immune system. Alterations in the bowel microbiome lead to altered innate and adaptive immune responses potentially relevant to the development or persistence of RA. SUMMARY: Microbes and the host response to microbes are important factors in the maintenance of health. Abnormalities or imbalances in these responses can lead to the development of autoimmune inflammatory conditions such as RA.
Authors: Giorgio Gabarrini; Stefano Grasso; Arie Jan van Winkelhoff; Jan Maarten van Dijl Journal: Microbiol Mol Biol Rev Date: 2020-01-02 Impact factor: 11.056
Authors: Michele Ciro Totaro; Paola Cattani; Francesco Ria; Barbara Tolusso; Elisa Gremese; Anna Laura Fedele; Sara D'Onghia; Simona Marchetti; Gabriele Di Sante; Silvia Canestri; Gianfranco Ferraccioli Journal: Arthritis Res Ther Date: 2013-06-18 Impact factor: 5.156