Nadia Shihab1, Jon Bowen, Holger A Volk. 1. Department of Veterinary Clinical Sciences, Royal Veterinary College, Hertfordshire, UK. nshihab@rvc.ac.uk
Abstract
OBJECTIVES: The aim of the study was to demonstrate behavioral changes with the development of epilepsy in dogs, a species proposed as a naturally occurring animal model for human epilepsy. METHODS: Owners of dogs diagnosed with idiopathic epilepsy (n=80) completed a modified, previously-validated behavioral and seizure questionnaire. Principal axis factor analysis identified behavioral factors, the scores for which were compared before and after the development of epilepsy. RESULTS: Drug-naïve dogs showed an increase in the behavior factors Fear/Anxiety, Defensive Aggression, and Abnormal Perception. In dogs receiving antiepileptic medication, there were still increases in Fear/Anxiety and Abnormal Perception, but no longer in Defensive Aggression. Additional increases were observed in Abnormal Reactivity, Attachment Disorder, Demented Behavior, and Apathetic Behavior. Pharmacoresistant dogs had larger increases in Controlling Aggression, Abnormal Perception, and Demented Behavior than drug responders. CONCLUSION: Our data suggest that dogs, like humans and rodents, exhibit neurobehavioral comorbidities with the development of epilepsy.
OBJECTIVES: The aim of the study was to demonstrate behavioral changes with the development of epilepsy in dogs, a species proposed as a naturally occurring animal model for humanepilepsy. METHODS: Owners of dogs diagnosed with idiopathic epilepsy (n=80) completed a modified, previously-validated behavioral and seizure questionnaire. Principal axis factor analysis identified behavioral factors, the scores for which were compared before and after the development of epilepsy. RESULTS: Drug-naïve dogs showed an increase in the behavior factors Fear/Anxiety, Defensive Aggression, and Abnormal Perception. In dogs receiving antiepileptic medication, there were still increases in Fear/Anxiety and Abnormal Perception, but no longer in Defensive Aggression. Additional increases were observed in Abnormal Reactivity, Attachment Disorder, Demented Behavior, and Apathetic Behavior. Pharmacoresistant dogs had larger increases in Controlling Aggression, Abnormal Perception, and Demented Behavior than drug responders. CONCLUSION: Our data suggest that dogs, like humans and rodents, exhibit neurobehavioral comorbidities with the development of epilepsy.
Authors: Luisa De Risio; Sofie Bhatti; Karen Muñana; Jacques Penderis; Veronika Stein; Andrea Tipold; Mette Berendt; Robyn Farqhuar; Andrea Fischer; Sam Long; Paul J J Mandigers; Kaspar Matiasek; Rowena M A Packer; Akos Pakozdy; Ned Patterson; Simon Platt; Michael Podell; Heidrun Potschka; Martí Pumarola Batlle; Clare Rusbridge; Holger A Volk Journal: BMC Vet Res Date: 2015-08-28 Impact factor: 2.741
Authors: Heidrun Potschka; Andrea Fischer; Wolfgang Löscher; Ned Patterson; Sofie Bhatti; Mette Berendt; Luisa De Risio; Robyn Farquhar; Sam Long; Paul Mandigers; Kaspar Matiasek; Karen Muñana; Akos Pakozdy; Jacques Penderis; Simon Platt; Michael Podell; Clare Rusbridge; Veronika Stein; Andrea Tipold; Holger A Volk Journal: BMC Vet Res Date: 2015-08-28 Impact factor: 2.741
Authors: T S Jokinen; K Tiira; L Metsähonkala; E H Seppälä; A Hielm-Björkman; H Lohi; O Laitinen-Vapaavuori Journal: J Vet Intern Med Date: 2015-05-06 Impact factor: 3.333