Literature DB >> 21531559

Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity.

Manuel Koller1, Kurt Lingenhoehl, Markus Schmutz, Ivan-Toma Vranesic, Joerg Kallen, Yves P Auberson, David A Carcache, Henri Mattes, Silvio Ofner, David Orain, Stephan Urwyler.   

Abstract

Quinazoline-2,4-diones with a sulfonamide group attached to the N(3) ring atom constitute a novel class of competitive AMPA receptor antagonists. One of the synthesized compounds, 28, shows nanomolar receptor affinity, whereas other examples of the series display oral anticonvulsant activity in animal models.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21531559     DOI： 10.1016/j.bmcl.2011.04.017

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Ionic liquid versus prodrug strategy to address formulation challenges.

Authors:  Anja Balk; Toni Widmer; Johannes Wiest; Heike Bruhn; Jens-Christoph Rybak; Philipp Matthes; Klaus Müller-Buschbaum; Anastasios Sakalis; Tessa Lühmann; Jörg Berghausen; Ulrike Holzgrabe; Bruno Galli; Lorenz Meinel
Journal:  Pharm Res       Date:  2014-12-23       Impact factor: 4.200

Review 2.  Size matters in activation/inhibition of ligand-gated ion channels.

Authors:  Juan Du; Hao Dong; Huan-Xiang Zhou
Journal:  Trends Pharmacol Sci       Date:  2012-07-11       Impact factor: 14.819

3.  Discovery of Quinazoline-2,4(1H,3H)-Dione Derivatives as Potential Antibacterial Agent: Design, Synthesis, and Their Antibacterial Activity.

Authors:  Nader M Boshta; Farag A El-Essawy; Mohammed B Alshammari; Safaa G Noreldein; Osama M Darwesh
Journal:  Molecules       Date:  2022-06-15       Impact factor: 4.927

Review 4.  AMPA receptors as a molecular target in epilepsy therapy.

Authors:  M A Rogawski
Journal:  Acta Neurol Scand Suppl       Date:  2013

5.  2,4-Dichloro-7-fluoro-quinazoline.

Authors:  Feng Gao; Yun-Fei Hu; Jin-Long Wang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-02-17

6.  Antitarget Interaction, Acute Toxicity and Protein Binding Studies of Quinazolinedione Sulphonamides as GABA1 Antagonists.

Authors:  Mansi Verma; Sangeeta Rani; A Kumar
Journal:  Indian J Pharm Sci       Date:  2016 Jan-Feb       Impact factor: 0.975

Review 7.  Antiepileptic drugs in development pipeline: A recent update.

Authors:  Harjeet Kaur; Baldeep Kumar; Bikash Medhi
Journal:  eNeurologicalSci       Date:  2016-06-17
  7 in total

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