| Literature DB >> 21531340 |
Daniel D Lam1, Gina M Leinninger, Gwendolyn W Louis, Alastair S Garfield, Oliver J Marston, Rebecca L Leshan, Erica L Scheller, Lyndsay Christensen, Jose Donato, Jing Xia, Mark L Evans, Carol Elias, Jeffrey W Dalley, Denis I Burdakov, Martin G Myers, Lora K Heisler.
Abstract
Serotonin (5-HT) and leptin play important roles in the modulation of energy balance. Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not express LepRb. Indeed, while leptin hyperpolarizes some non-5-HT DR neurons, leptin does not alter the activity of DR 5-HT neurons. Furthermore, 5-HT depletion does not impair the anorectic effects of leptin. The serotonin transporter-cre allele (Sert(cre)) is expressed in 5-HT (and developmentally in some non-5-HT) neurons. While Sert(cre) promotes LepRb excision in a few LepRb neurons in the hypothalamus, it is not active in DR LepRb neurons, and neuron-specific Sert(cre)-mediated LepRb inactivation in mice does not alter body weight or adiposity. Thus, leptin does not directly influence 5-HT neurons and does not meaningfully modulate important appetite-related determinants via 5-HT neuron function.Entities:
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Year: 2011 PMID： 21531340 PMCID： PMC3087147 DOI： 10.1016/j.cmet.2011.03.016
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287