BACKGROUND: Asthma exacerbations are the commonest cause of medical admissions in childhood. These have a significant effect on quality of life and are a major financial burden on worldwide healthcare services. A range of gene-environment interactions may influence the course and severity of asthma in children and their response to medication. The Chitinase 3-like 1 (CHI3L1)-131C>G genotype (rs4950928) is associated with increased asthma susceptibility and severity in adults. OBJECTIVES: To study the interactions of the Chitinase 3-Like-1 functional promoter SNP rs4950928 and its role on asthma exacerbations in a population of children and young adults with asthma. METHODS: A cross-sectional survey was undertaken using medical records and direct interviews of 1,071 children and young adults with asthma, aged 3 to 22 years, from Scotland. Saliva samples were collected for genotyping. Binary logistic regression was used to calculate odds ratios (ORs) and P-values for measures of asthma exacerbations. RESULTS: The minor -131G allele confers protection against asthma-related hospital admissions (OR = 0.62; 95% CI 0.41-0.92; P = .018) in children and young adults with asthma. CONCLUSIONS: Our study shows that rs4950928 is significantly associated with hospital admissions in children and young adults; screening for rs4950928 may predict asthma-related hospital admissions, and through individually defined treatment management plans, potentially reduce health care costs.
BACKGROUND: Asthma exacerbations are the commonest cause of medical admissions in childhood. These have a significant effect on quality of life and are a major financial burden on worldwide healthcare services. A range of gene-environment interactions may influence the course and severity of asthma in children and their response to medication. The Chitinase 3-like 1 (CHI3L1)-131C>G genotype (rs4950928) is associated with increased asthma susceptibility and severity in adults. OBJECTIVES: To study the interactions of the Chitinase 3-Like-1 functional promoter SNP rs4950928 and its role on asthma exacerbations in a population of children and young adults with asthma. METHODS: A cross-sectional survey was undertaken using medical records and direct interviews of 1,071 children and young adults with asthma, aged 3 to 22 years, from Scotland. Saliva samples were collected for genotyping. Binary logistic regression was used to calculate odds ratios (ORs) and P-values for measures of asthma exacerbations. RESULTS: The minor -131G allele confers protection against asthma-related hospital admissions (OR = 0.62; 95% CI 0.41-0.92; P = .018) in children and young adults with asthma. CONCLUSIONS: Our study shows that rs4950928 is significantly associated with hospital admissions in children and young adults; screening for rs4950928 may predict asthma-related hospital admissions, and through individually defined treatment management plans, potentially reduce health care costs.
Authors: Xiting Yan; Jen-Hwa Chu; Jose Gomez; Maria Koenigs; Carole Holm; Xiaoxuan He; Mario F Perez; Hongyu Zhao; Shrikant Mane; Fernando D Martinez; Carole Ober; Dan L Nicolae; Kathleen C Barnes; Stephanie J London; Frank Gilliland; Scott T Weiss; Benjamin A Raby; Lauren Cohn; Geoffrey L Chupp Journal: Am J Respir Crit Care Med Date: 2015-05-15 Impact factor: 21.405
Authors: Brian B Graham; Jacob Chabon; Rahul Kumar; Ewa Kolosionek; Liya Gebreab; Elias Debella; Michael Edwards; Katrina Diener; Ted Shade; Gao Bifeng; Angela Bandeira; Ghazwan Butrous; Kenneth Jones; Mark Geraci; Rubin M Tuder Journal: Am J Respir Cell Mol Biol Date: 2013-12 Impact factor: 6.914
Authors: Michael J McGeachie; Ann C Wu; Sze Man Tse; George L Clemmer; Joanne Sordillo; Blanca E Himes; Jessica Lasky-Su; Robert P Chase; Fernando D Martinez; Peter Weeke; Christian M Shaffer; Hua Xu; Josh C Denny; Dan M Roden; Reynold A Panettieri; Benjamin A Raby; Scott T Weiss; Kelan G Tantisira Journal: J Allergy Clin Immunol Date: 2015-06-12 Impact factor: 10.793
Authors: Simone Accordini; Lucia Calciano; Cristina Bombieri; Giovanni Malerba; Francesca Belpinati; Anna Rita Lo Presti; Alessandro Baldan; Marcello Ferrari; Luigi Perbellini; Roberto de Marco Journal: PLoS One Date: 2016-03-17 Impact factor: 3.240
Authors: Jakob W Hansen; Simon F Thomsen; Celeste Porsbjerg; Linda M Rasmussen; Lotte Harmsen; Julia S Johansen; Vibeke Backer Journal: Eur Clin Respir J Date: 2015-09-16