| Literature DB >> 21530613 |
D A Wilson1, M J Hoptman, S V Gerum, D N Guilfoyle.
Abstract
Functional connectivity between the piriform cortex and limbic and neocortical areas was assessed using functional magnetic resonance imaging (fMRI) of urethane anesthetized rats that spontaneously cycled between slow-wave and fast-wave states. Slow-wave and fast-wave states were determined indirectly through monitoring of respiration rate, which was confirmed to co-vary with state as determined by electrophysiological recordings. Previous electrophysiological data have suggested that the piriform cortex shifts between responsiveness to afferent odor input during fast-wave states and enhanced functional connectivity with limbic areas during slow-wave state. The present results demonstrate that fMRI-based resting state functional connectivity between the piriform cortex and both limbic and neocortical areas is enhanced during slow-wave state compared to fast-wave state using respiration as an indirect measure of state in urethane anesthetized rats. This state-dependent shift in functional connectivity may be important for sleep-dependent odor memory consolidation.Entities:
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Year: 2011 PMID： 21530613 PMCID： PMC3103633 DOI： 10.1016/j.neulet.2011.04.031
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046