| Literature DB >> 21530246 |
Alexandre Vogrig1, Benjamin Boucherle, Hemantkumar Deokar, Isabelle Thomas, Isabelle Ripoche, Lu-Yun Lian, Sylvie Ducki.
Abstract
We synthesized small organic molecules designed as PDZ ligands. These indole-based compounds were evaluated for their interaction with the PDZ1 domain of the post-synaptic density 95 (PSD-95) protein. Three molecules were found to interact with the targeted PDZ protein by NMR. One of them showed chemical shift perturbations closely related to the natural ligands.Entities:
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Year: 2011 PMID： 21530246 DOI： 10.1016/j.bmcl.2011.04.011
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823