OBJECTIVE: Behavioral therapies developed specifically for co-occurring disorders remain sparse, and such therapies for comorbid adolescents are particularly rare. This was an evaluation of the long-term (2-year) efficacy of an acute phase trial of manualized cognitive behavioral therapy/motivation enhancement therapy (CBT/MET) vs. naturalistic treatment among adolescents who had signed consent for a treatment study involving the SSRI antidepressant medication fluoxetine and CBT/MET therapy for comorbid major depressive disorder (MDD) and an alcohol use disorder (AUD). We hypothesized that improvements in depressive symptoms and alcohol-related symptoms noted among the subjects who had received CBT/MET would exceed that of those in the naturalistic comparison group that had not received CBT/MET therapy. METHODS: We evaluated levels of depressive symptoms and alcohol-related symptoms at a two-year follow-up evaluation among comorbid MDD/AUD adolescents who had received an acute phase trial of manual-based CBT/MET (in addition to the SSRI medicationfluoxetine or placebo) compared to those who had received naturalistic care. RESULTS: In repeated measures ANOVA, a significant time by enrollment status difference was noted for both depressive symptoms and alcohol-related symptoms across the two-year time period of this study, with those receiving CBT/MET demonstrating superior outcomes compared to those who had not received protocol CBT/MET therapy. No significant difference was noted between those receiving fluoxetine vs. those receiving placebo on any outcome at any time point. CONCLUSIONS: These findings suggest long-term efficacy for an acute phase trial of manualized CBT/MET for treating comorbid MDD/AUD adolescents. Large multi-site studies are warranted to further clarify the efficacy of CBT/MET therapy among various adolescent and young adult comorbid populations.
RCT Entities:
OBJECTIVE: Behavioral therapies developed specifically for co-occurring disorders remain sparse, and such therapies for comorbid adolescents are particularly rare. This was an evaluation of the long-term (2-year) efficacy of an acute phase trial of manualized cognitive behavioral therapy/motivation enhancement therapy (CBT/MET) vs. naturalistic treatment among adolescents who had signed consent for a treatment study involving the SSRI antidepressant medication fluoxetine and CBT/MET therapy for comorbid major depressive disorder (MDD) and an alcohol use disorder (AUD). We hypothesized that improvements in depressive symptoms and alcohol-related symptoms noted among the subjects who had received CBT/MET would exceed that of those in the naturalistic comparison group that had not received CBT/MET therapy. METHODS: We evaluated levels of depressive symptoms and alcohol-related symptoms at a two-year follow-up evaluation among comorbid MDD/AUD adolescents who had received an acute phase trial of manual-based CBT/MET (in addition to the SSRI medication fluoxetine or placebo) compared to those who had received naturalistic care. RESULTS: In repeated measures ANOVA, a significant time by enrollment status difference was noted for both depressive symptoms and alcohol-related symptoms across the two-year time period of this study, with those receiving CBT/MET demonstrating superior outcomes compared to those who had not received protocol CBT/MET therapy. No significant difference was noted between those receiving fluoxetine vs. those receiving placebo on any outcome at any time point. CONCLUSIONS: These findings suggest long-term efficacy for an acute phase trial of manualized CBT/MET for treating comorbid MDD/AUD adolescents. Large multi-site studies are warranted to further clarify the efficacy of CBT/MET therapy among various adolescent and young adult comorbid populations.
Authors: J R Cornelius; O G Bukstein; B Birmaher; I M Salloum; K Lynch; N K Pollock; S Gershon; D Clark Journal: Addict Behav Date: 2001 Sep-Oct Impact factor: 3.913
Authors: Jack R Cornelius; Oscar G Bukstein; Ihsan M Salloum; Thomas M Kelly; D Scott Wood; Duncan B Clark Journal: J Child Adolesc Psychopharmacol Date: 2004 Impact factor: 2.576
Authors: Jack R Cornelius; Howard J Aizenstein; Tammy A Chung; Antoine Douaihy; Jeanine Hayes; Dennis Daley; Ihsan M Salloum Journal: Adv Psychol Res Date: 2013
Authors: Mary Clair-Michaud; Rosemarie A Martin; Linda A R Stein; Shayna Bassett; Rebecca Lebeau; Charles Golembeske Journal: J Subst Abuse Treat Date: 2015-09-25
Authors: Jack R Cornelius; Tammy Chung; Antoine B Douaihy; Levent Kirisci; Jody Glance; Julie Kmiec; Douglas FitzGerald; Maribeth A Wesesky; Ihsan Salloum Journal: Psychiatry Res Date: 2016-06-15 Impact factor: 3.222
Authors: Jack R Cornelius; Antoine B Douaihy; Duncan B Clark; Dennis C Daley; Tammy A Chung; Maribeth A Wesesky; D Scott Wood; Ihsan Salloum Journal: J Addict Behav Ther Rehabil Date: 2013-08-24