Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Protease power strokes force proteins to unfold.

Literature DB >> 21529709

Protease power strokes force proteins to unfold.

Jorge Alegre-Cebollada¹, Pallav Kosuri, Julio M Fernández.

Abstract

ATP-dependent proteases degrade proteins in the cytosol of cells. Two recent articles, by Aubin-Tam et al. (2011) and Maillard et al. (2011 [this issue]), use single-molecule optical tweezers to show directly that these molecular machines use the energy derived from ATP hydrolysis to mechanically unfold and translocate its substrates into the proteolytic chamber.

Entities: Chemical Disease Gene Species

Year: 2011 PMID： 21529709 PMCID： PMC4676939 DOI： 10.1016/j.cell.2011.04.007

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

10 in total

1. Unraveling the means to the end in ATP-dependent proteases.

Authors: M Hochstrasser; J Wang
Journal: Nat Struct Biol Date: 2001-04

2. Impairment of the ubiquitin-proteasome system by protein aggregation.

Authors: N F Bence; R M Sampat; R R Kopito
Journal: Science Date: 2001-05-25 Impact factor: 47.728

3. The unfolding kinetics of ubiquitin captured with single-molecule force-clamp techniques.

Authors: Michael Schlierf; Hongbin Li; Julio M Fernandez
Journal: Proc Natl Acad Sci U S A Date: 2004-04-27 Impact factor: 11.205

Review 4. The protein folding 'speed limit'.

Authors: Jan Kubelka; James Hofrichter; William A Eaton
Journal: Curr Opin Struct Biol Date: 2004-02 Impact factor: 6.809

1 in total

1. Protein unfolding by biological unfoldases: insights from modeling.

Authors: Michał Wojciechowski; Piotr Szymczak; Mariano Carrión-Vázquez; Marek Cieplak
Journal: Biophys J Date: 2014-10-07 Impact factor: 4.033

1 in total

Protease power strokes force proteins to unfold.

1. Unraveling the means to the end in ATP-dependent proteases.

2. Impairment of the ubiquitin-proteasome system by protein aggregation.

3. The unfolding kinetics of ubiquitin captured with single-molecule force-clamp techniques.

Review 4. The protein folding 'speed limit'.

5. Force-clamp spectroscopy monitors the folding trajectory of a single protein.

6. Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine.

7. Direct observation of an ensemble of stable collapsed states in the mechanical folding of ubiquitin.

8. Mechanical unfolding of single filamin A (ABP-280) molecules detected by atomic force microscopy.

9. ClpX(P) generates mechanical force to unfold and translocate its protein substrates.

10. Single homopolypeptide chains collapse into mechanically rigid conformations.

1. Protein unfolding by biological unfoldases: insights from modeling.