| Literature DB >> 21528845 |
Thomas Pesnot1, Julia Kempter, Jörg Schemies, Giulia Pergolizzi, Urszula Uciechowska, Tobias Rumpf, Wolfgang Sippl, Manfred Jung, Gerd K Wagner.
Abstract
We report the design and concise synthesis, in two steps from commercially available material, of novel, bioactive derivatives of the enzyme cofactor nicotinamide adenine dinucleotide (NAD). The new synthetic dinucleotides act as sirtuin (SIRT) inhibitors and show isoform selectivity for SIRT2 over SIRT1. An NMR-based conformational analysis suggests that the conformational preferences of individual analogues may contribute to their isoform selectivity.Entities:
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Year: 2011 PMID： 21528845 DOI： 10.1021/jm1013852
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446