Nurullah Celik1, Nesibe Andiran. 1. Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, Fatih University, Ankara, Turkey. celiknurullah@hotmail.com
Abstract
AIM: To investigate the relationship between serum phosphate levels with obesity and insulin resistance in childhood. METHODS: A total of 298 children and adolescents (190 obese subjects and 108 controls) were included in the study. Serum glucose, insulin, phosphate, calcium and alkaline phosphatase levels were measured after 12 h fasting at 08:00-08:30 h. We assessed insulin sensitivity by using the HOMA-IR (homeostasis model of insulin resistance) index as a surrogate marker of insulin resistance. RESULTS: Serum levels of phosphate were significantly lower in the 6- to 12-year-old obese subjects than controls (p = 0.02, p < 0.05). At the same time, there was a moderate negative correlation between serum phosphate levels and the HOMA-IR index in the 6- to 12-year-old IR (-) obese children (r = -0.26, p = 0.02). CONCLUSIONS: Low serum phosphate levels could contribute to the development of insulin resistance in 6- to 12-year-old obese children.
AIM: To investigate the relationship between serum phosphate levels with obesity and insulin resistance in childhood. METHODS: A total of 298 children and adolescents (190 obese subjects and 108 controls) were included in the study. Serum glucose, insulin, phosphate, calcium and alkaline phosphatase levels were measured after 12 h fasting at 08:00-08:30 h. We assessed insulin sensitivity by using the HOMA-IR (homeostasis model of insulin resistance) index as a surrogate marker of insulin resistance. RESULTS: Serum levels of phosphate were significantly lower in the 6- to 12-year-old obese subjects than controls (p = 0.02, p < 0.05). At the same time, there was a moderate negative correlation between serum phosphate levels and the HOMA-IR index in the 6- to 12-year-old IR (-) obesechildren (r = -0.26, p = 0.02). CONCLUSIONS: Low serum phosphate levels could contribute to the development of insulin resistance in 6- to 12-year-old obesechildren.
Authors: Lukasz Szczerbinski; Gladys Wojciechowska; Adam Olichwier; Mark A Taylor; Urszula Puchta; Paulina Konopka; Adam Paszko; Anna Citko; Joanna Goscik; Oliver Fiehn; Sili Fan; Anna Wasilewska; Katarzyna Taranta-Janusz; Adam Kretowski Journal: Nutrients Date: 2022-01-04 Impact factor: 5.717