Literature DB >> 21528409

Co-existence of t(6;13)(p21;q14.1) and trisomy 12 in chronic lymphocytic leukemia.

Fábio Morato de Oliveira1, Lorena Lobo de Figueiredo Pontes, Sarah Cristina Bassi, Leandro Felipe Figueiredo Dalmazzo, Roberto Passetto Falcão.   

Abstract

We report a case of a 57-year-old man diagnosed with chronic lymphocytic leukemia (CLL) and presence of a rare t(6;13)(p21;q14.1) in association with an extra copy of chromosome 12. Classical cytogenetic analysis using the immunostimulatory combination of DSP30 and IL-2 showed the karyotype 47,XY,t(6;13)(p21;q14.1), +12 in 75% of the metaphase cells. Spectral karyotype analysis (SKY) confirmed the abnormality previously seen by G-banding. Additionally, interphase fluorescence in situ hybridization using an LSI CEP 12 probe performed on peripheral blood cells without any stimulant agent showed trisomy of chromosome 12 in 67% of analyzed cells (134/200). To the best of our knowledge, the association of t(6;13)(p21;q14.1) and +12 in CLL has never been described. The prognostic significance of these new findings in CLL remains to be elucidated. However, the patient has been followed up since 2009 without any therapeutic intervention and has so far remained stable.

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Mesh：

Year:  2011        PMID： 21528409     DOI： 10.1007/s12032-011-9957-1

Source DB:  PubMed          Journal:  Med Oncol        ISSN： 1357-0560            Impact factor:   3.064


  18 in total

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2.  Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotyping.

Authors:  C Haferlach; F Dicker; S Schnittger; W Kern; T Haferlach
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3.  Cytogenetic, fluorescence in situ hybridisation, and clinical evaluation of translocations with concomitant deletion at 13q14 in chronic lymphocytic leukaemia.

Authors:  A C Gardiner; M M Corcoran; D G Oscier
Journal:  Genes Chromosomes Cancer       Date:  1997-09       Impact factor: 5.006

4.  Chromosome 6p rearrangements appear to be secondary changes in various haematological malignancies.

Authors:  J L Huret; M Schoenwald; A Brizard; F Guilhot; E Vilmer; J Tanzer
Journal:  Leuk Res       Date:  1989       Impact factor: 3.156

5.  Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia.

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6.  Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia.

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7.  Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies.

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Review 10.  New insights into the pathogenesis of chronic lymphocytic leukemia.

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Journal:  Semin Cancer Biol       Date:  2010-10-26       Impact factor: 15.707
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