Literature DB >> 2152824

Defective viral DNA in Epstein-Barr virus-associated oral hairy leukoplakia.

D F Patton1, P Shirley, N Raab-Traub, L Resnick, J W Sixbey.   

Abstract

Defective Epstein-Barr virus (EBV) has a deleted and rearranged genome (termed het DNA) that disrupts latency and induces standard EBV to replicate in vitro. We used the polymerase chain reaction to detect, in 2 of 10 patient samples, the junction of abnormally juxtaposed EBV DNA fragments BamHI W and Z, a genomic rearrangement responsible for the biologic activity of het DNA. By sequence analysis, the junction in wild-type defective DNA appears to be similar but not identical to the recombination in the DNA of laboratory strain P3HR-1. The presence of this marker for het DNA in the epithelial lesions of two patients suggests a role for defective EBV in a human pathologic process.

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Year:  1990        PMID： 2152824      PMCID： PMC249114     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

1.  Recovery of transforming EBV from non-producer cells after superinfection with non-transforming P3HR-1 EBV.

Authors:  K O Fresen; M S Cho; H zur Hausen
Journal:  Int J Cancer       Date:  1978-10-15       Impact factor: 7.396

2.  Nucleic acid renaturation and restriction endonuclease cleavage analyses show that the DNAs of a transforming and a nontransforming strain of Epstein-Barr virus share approximately 90% of their nucleotide sequences.

Authors:  B Sugden; W C Summers; G Klein
Journal:  J Virol       Date:  1976-05       Impact factor: 5.103

3.  Screening lambdagt recombinant clones by hybridization to single plaques in situ.

Authors:  W D Benton; R W Davis
Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

4.  Epstein-Barr virus DNA. IX. Variation among viral DNAs from producer and nonproducer infected cells.

Authors:  M Heller; T Dambaugh; E Kieff
Journal:  J Virol       Date:  1981-05       Impact factor: 5.103

5.  Epstein-Barr virus with heterogeneous DNA disrupts latency.

Authors:  G Miller; M Rabson; L Heston
Journal:  J Virol       Date:  1984-04       Impact factor: 5.103

6.  P3HR-1 Epstein-Barr virus with heterogeneous DNA is an independent replicon maintained by cell-to-cell spread.

Authors:  G Miller; L Heston; J Countryman
Journal:  J Virol       Date:  1985-04       Impact factor: 5.103

7.  Structure of defective DNA molecules in Epstein-Barr virus preparations from P3HR-1 cells.

Authors:  M S Cho; G W Bornkamm; H zur Hausen
Journal:  J Virol       Date:  1984-07       Impact factor: 5.103

8.  Epstein-Barr virus replication in oropharyngeal epithelial cells.

Authors:  J W Sixbey; J G Nedrud; N Raab-Traub; R A Hanes; J S Pagano
Journal:  N Engl J Med       Date:  1984-05-10       Impact factor: 91.245

9.  Non-immortalizing P3J-HR-1 Epstein-Barr virus: a deletion mutant of its transforming parent, Jijoye.

Authors:  M Rabson; L Gradoville; L Heston; G Miller
Journal:  J Virol       Date:  1982-12       Impact factor: 5.103

10.  Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells.

Authors:  M Rabson; L Heston; G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205
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  16 in total

1.  Coinfection with multiple strains of the Epstein-Barr virus in human immunodeficiency virus-associated hairy leukoplakia.

Authors:  D M Walling; S N Edmiston; J W Sixbey; M Abdel-Hamid; L Resnick; N Raab-Traub
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

2.  Marked variation in the size of genomic plasmids among members of a family of related Epstein-Barr viruses.

Authors:  J L Kolman; C J Kolman; G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

Review 3.  Epstein-Barr virus infection at mucosal surfaces: detection of genomic variants with altered pathogenic potential.

Authors:  J W Sixbey; P Shirley
Journal:  Springer Semin Immunopathol       Date:  1991

4.  Epstein-Barr virus induction of recombinase-activating genes RAG1 and RAG2.

Authors:  S K Srinivas; J W Sixbey
Journal:  J Virol       Date:  1995-12       Impact factor: 5.103

5.  Autoantigenic proteins that bind recombinogenic sequences in Epstein-Barr virus and cellular DNA.

Authors:  R Sun; T A Spain; S F Lin; G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-30       Impact factor: 11.205

6.  Epithelial cell retention of transcriptionally active, P3HR-1-derived heterogeneous Epstein-Barr virus DNA with concurrent loss of parental virus.

Authors:  Kazufumi Ikuta; Mingyu Ding; Fangfang Zhang; John W Sixbey; Rona S Scott
Journal:  J Virol       Date:  2011-05-18       Impact factor: 5.103

7.  Epstein-Barr virus intrastrain recombination in oral hairy leukoplakia.

Authors:  D M Walling; N Raab-Traub
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

8.  The Epstein-Barr virus EBNA-2 gene in oral hairy leukoplakia: strain variation, genetic recombination, and transcriptional expression.

Authors:  D M Walling; A G Perkins; J Webster-Cyriaque; L Resnick; N Raab-Traub
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

9.  Thymic neoplasm: a rare disease with a complex clinical presentation.

Authors:  Omar M Rashid; Anthony D Cassano; Kazuaki Takabe
Journal:  J Thorac Dis       Date:  2013-04       Impact factor: 2.895

10.  Points of recombination in Epstein-Barr virus (EBV) strain P3HR-1-derived heterogeneous DNA as indexes to EBV DNA recombinogenic events in vivo.

Authors:  Kazufumi Ikuta; Shamala K Srinivas; Tim Schacker; Jun-ichi Miyagi; Rona S Scott; John W Sixbey
Journal:  J Virol       Date:  2008-09-25       Impact factor: 5.103
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