AIM: To identify factors predicting the clinical response of ulcerative colitis patients to granulocyte-monocyte apheresis (GMA). METHODS: Sixty-nine ulcerative colitis patients (39 F, 30 M) dependent upon/refractory to steroids were treated with GMA. Steroid dependency, clinical activity index (CAI), C reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), values at baseline, use of immunosuppressant, duration of disease, and age and extent of disease were considered for statistical analysis as predictive factors of clinical response. Univariate and multivariate logistic regression models were used. RESULTS: In the univariate analysis, CAI (P = 0.039) and ESR (P = 0.017) levels at baseline were singled out as predictive of clinical remission. In the multivariate analysis steroid dependency [Odds ratio (OR) = 0.390, 95% Confidence interval (CI): 0.176-0.865, Wald 5.361, P = 0.0160] and low CAI levels at baseline (4 < CAI < 7) (OR = 0.770, 95% CI: 0.425-1.394, Wald 3.747, P = 0.028) proved to be effective as factors predicting clinical response. CONCLUSION: GMA may be a valid therapeutic option for steroid-dependent ulcerative colitis patients with mild-moderate disease and its clinical efficacy seems to persist for 12 mo.
AIM: To identify factors predicting the clinical response of ulcerative colitispatients to granulocyte-monocyte apheresis (GMA). METHODS: Sixty-nine ulcerative colitispatients (39 F, 30 M) dependent upon/refractory to steroids were treated with GMA. Steroid dependency, clinical activity index (CAI), C reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), values at baseline, use of immunosuppressant, duration of disease, and age and extent of disease were considered for statistical analysis as predictive factors of clinical response. Univariate and multivariate logistic regression models were used. RESULTS: In the univariate analysis, CAI (P = 0.039) and ESR (P = 0.017) levels at baseline were singled out as predictive of clinical remission. In the multivariate analysis steroid dependency [Odds ratio (OR) = 0.390, 95% Confidence interval (CI): 0.176-0.865, Wald 5.361, P = 0.0160] and low CAI levels at baseline (4 < CAI < 7) (OR = 0.770, 95% CI: 0.425-1.394, Wald 3.747, P = 0.028) proved to be effective as factors predicting clinical response. CONCLUSION: GMA may be a valid therapeutic option for steroid-dependent ulcerative colitispatients with mild-moderate disease and its clinical efficacy seems to persist for 12 mo.
Authors: Wolfgang Kruis; Axel Dignass; Elisabeth Steinhagen-Thiessen; Julia Morgenstern; Joachim Mössner; Stephan Schreiber; Maurizio Vecchi; Alberto Malesci; Max Reinshagen; Robert Löfberg Journal: World J Gastroenterol Date: 2005-11-28 Impact factor: 5.742
Authors: K Takemoto; J Kato; M Kuriyama; T Nawa; M Kurome; H Okada; K Sakaguchi; Y Shiratori Journal: Dig Liver Dis Date: 2007-03-26 Impact factor: 4.088
Authors: J L Cabriada; E Domènech; N Ibargoyen; V Hernández; J Clofent; D Ginard; I Gutiérrez-Ibarluzea; J Hinojosa Journal: J Gastroenterol Date: 2011-11-23 Impact factor: 7.527