Literature DB >> 21527953

Mitotic catastrophe: a mechanism for avoiding genomic instability.

Ilio Vitale1, Lorenzo Galluzzi, Maria Castedo, Guido Kroemer.   

Abstract

The improper distribution of chromosomes during mitosis compromises cellular functions and can reduce cellular fitness or contribute to malignant transformation. As a countermeasure, higher eukaryotes have developed strategies for eliminating mitosis-incompetent cells, one of which is mitotic catastrophe. Mitotic catastrophe is driven by a complex and poorly understood signalling cascade but, from a functional perspective, it can be defined as an oncosuppressive mechanism that precedes (and is distinct from) apoptosis, necrosis or senescence. Accordingly, the disruption of mitotic catastrophe precipitates tumorigenesis and cancer progression, and its induction constitutes a therapeutic endpoint.

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Year:  2011        PMID： 21527953     DOI： 10.1038/nrm3115

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  97 in total

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Journal:  Int J Radiat Biol       Date:  1997-10       Impact factor: 2.694

Review 2.  Death through a tragedy: mitotic catastrophe.

Authors:  H Vakifahmetoglu; M Olsson; B Zhivotovsky
Journal:  Cell Death Differ       Date:  2008-04-11       Impact factor: 15.828

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Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

4.  Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.

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Journal:  Cancer Cell       Date:  2006-12-28       Impact factor: 31.743

Review 5.  Molecular mechanisms of necroptosis: an ordered cellular explosion.

Authors:  Peter Vandenabeele; Lorenzo Galluzzi; Tom Vanden Berghe; Guido Kroemer
Journal:  Nat Rev Mol Cell Biol       Date:  2010-09-08       Impact factor: 94.444

6.  Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway.

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Journal:  Cancer Res       Date:  2007-01-15       Impact factor: 12.701

7.  A tumor suppressor function for caspase-2.

Authors:  Lien Ha Ho; Robyn Taylor; Loretta Dorstyn; Dimitrios Cakouros; Philippe Bouillet; Sharad Kumar
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-11       Impact factor: 11.205

Review 8.  Survivin, cancer networks and pathway-directed drug discovery.

Authors:  Dario C Altieri
Journal:  Nat Rev Cancer       Date:  2008-01       Impact factor: 60.716

9.  DNA damage induces two distinct modes of cell death in ovarian carcinomas.

Authors:  H Vakifahmetoglu; M Olsson; C Tamm; N Heidari; S Orrenius; B Zhivotovsky
Journal:  Cell Death Differ       Date:  2007-12-07       Impact factor: 15.828

Review 10.  The spindle-assembly checkpoint in space and time.

Authors:  Andrea Musacchio; Edward D Salmon
Journal:  Nat Rev Mol Cell Biol       Date:  2007-04-11       Impact factor: 94.444
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  360 in total

1.  Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

Authors:  Giuseppe La Regina; Ruoli Bai; Willeke Rensen; Antonio Coluccia; Francesco Piscitelli; Valerio Gatti; Alessio Bolognesi; Antonio Lavecchia; Ilaria Granata; Amalia Porta; Bruno Maresca; Alessandra Soriani; Maria Luisa Iannitto; Marisa Mariani; Angela Santoni; Andrea Brancale; Cristiano Ferlini; Giulio Dondio; Mario Varasi; Ciro Mercurio; Ernest Hamel; Patrizia Lavia; Ettore Novellino; Romano Silvestri
Journal:  J Med Chem       Date:  2011-11-21       Impact factor: 7.446

Review 2.  The secret ally: immunostimulation by anticancer drugs.

Authors:  Lorenzo Galluzzi; Laura Senovilla; Laurence Zitvogel; Guido Kroemer
Journal:  Nat Rev Drug Discov       Date:  2012-02-03       Impact factor: 84.694

3.  Cre recombinase induces DNA damage and tetraploidy in the absence of loxP sites.

Authors:  Vaibhao C Janbandhu; Daniel Moik; Reinhard Fässler
Journal:  Cell Cycle       Date:  2013-11-26       Impact factor: 4.534

4.  Immunosurveillance against tetraploidization-induced colon tumorigenesis.

Authors:  Alice Boilève; Laura Senovilla; Ilio Vitale; Delphine Lissa; Isabelle Martins; Didier Métivier; Stieneke van den Brink; Hans Clevers; Lorenzo Galluzzi; Maria Castedo; Guido Kroemer
Journal:  Cell Cycle       Date:  2013-01-16       Impact factor: 4.534

5.  Plk1-Mediated Phosphorylation of TSC1 Enhances the Efficacy of Rapamycin.

Authors:  Zhiguo Li; Yifan Kong; Longzhen Song; Qian Luo; Jinghui Liu; Chen Shao; Xianzeng Hou; Xiaoqi Liu
Journal:  Cancer Res       Date:  2018-03-20       Impact factor: 12.701

6.  Inhibiting p21-Activated Kinase Induces Cell Death in Vestibular Schwannoma and Meningioma via Mitotic Catastrophe.

Authors:  Melania Ester Mercado-Pimentel; Craig Miller; Daniela N Rolph; Edrick F Villalobos; Allison M Dunn; Prithvi M Mohan; Suzu Igarashi; Xiangdang Liu; Macken Yrun-Duffy; Neal K Patel; Cecilia M Read; Ross H Francis; Adelina Isabella Lane; Swaroop Murugesh; Abraham Jacob
Journal:  Otol Neurotol       Date:  2017-01       Impact factor: 2.311

7.  Induction of mitotic catastrophe by PKC inhibition in Nf1-deficient cells.

Authors:  Xiaodong Zhou; Sung-Hoon Kim; Ling Shen; Hyo-Jung Lee; Changyan Chen
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

8.  Protein kinase C β inhibition by enzastaurin leads to mitotic missegregation and preferential cytotoxicity toward colorectal cancer cells with chromosomal instability (CIN).

Authors:  Djamila Ouaret; Annette K Larsen
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

9.  microRNA-34a promotes DNA damage and mitotic catastrophe.

Authors:  Alexander V Kofman; Jungeun Kim; So Yeon Park; Evan Dupart; Christopher Letson; Yongde Bao; Kai Ding; Quan Chen; David Schiff; James Larner; Roger Abounader
Journal:  Cell Cycle       Date:  2013-09-19       Impact factor: 4.534

10.  Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells.

Authors:  Sylvia S Gayle; Jennifer M Sahni; Bryan M Webb; Kristen L Weber-Bonk; Melyssa S Shively; Raffaella Spina; Eli E Bar; Mathew K Summers; Ruth A Keri
Journal:  J Biol Chem       Date:  2018-11-27       Impact factor: 5.157
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