Literature DB >> 21526849

ZrCl4-mediated regio- and chemoselective Friedel-Crafts acylation of indole.

Sankar K Guchhait1, Maneesh Kashyap, Harshad Kamble.   

Abstract

An efficient method for regio- and chemoselective Friedel-Crafts acylation of indole using acyl chlorides in the presence of ZrCl(4) has been discovered. It minimizes/eliminates common competing reactions that occur due to high and multiatom-nucleophilic character of indole. In this method, a wide range of aroyl, heteroaroyl alkenoyl, and alkanoyl chlorides undergo smooth acylation with various indoles without NH protection and afford 3-acylindoles in good to high yields.

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Year:  2011        PMID： 21526849     DOI： 10.1021/jo200561f

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  6 in total

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5.  A General and Scalable Synthesis of Polysubstituted Indoles.

Authors:  David Tejedor; Raquel Diana-Rivero; Fernando García-Tellado
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6.  Diindolylmethane Derivatives: New Selective Blockers for T-Type Calcium Channels.

Authors:  Dan Wang; Pratik Neupane; Lotten Ragnarsson; Robert J Capon; Richard J Lewis
Journal:  Membranes (Basel)       Date:  2022-07-30
  6 in total

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