| Literature DB >> 21526273 |
Katharinne I Moraes de Carvalho1, Hélio B Fernandes, Flávia D Frota Machado, Irisdalva S Oliveira, Francisco A Oliveira, Paulo Humberto M Nunes, Julianeli T Lima, Jackson R G Silva Almeida, Rita C Meneses Oliveira.
Abstract
This study evaluated the antiulcer activity of an ethanolic extract of Encholirium spectabile (ES-EtOH) by using different standard experimental models of induced acute gastric ulceration. ES-EtOH (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by absolute ethanol (53%), ethanol/HCl (75%), ibuprofen (52 %) and ischemia/reperfusion (43 %). It also restored catalase activity and non-protein sulfhydryl group concentration in the gastric wall of mice that had been treated with ethanol. The pre-treatment of mice with N-nitro-L-arginine (70 mg/kg i.p.) abolished the protective activity of ES-EtOH, which indicates that prostaglandins, antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective activity of the extract.Entities:
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Year: 2011 PMID： 21526273 DOI： /S0716-97602010000400011
Source DB: PubMed Journal: Biol Res ISSN： 0716-9760 Impact factor: 5.612