Literature DB >> 21525956

Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast.

Nahid Iglesias1, Sophie Redon, Verena Pfeiffer, Martina Dees, Joachim Lingner, Brian Luke.   

Abstract

Telomeric repeat-containing RNA (TERRA) has been implicated in the control of heterochromatin and telomerase. We demonstrate that yeast TERRA is regulated by telomere-binding proteins in a chromosome-end-specific manner that is dependent on subtelomeric repetitive DNA elements. At telomeres that contain only X-elements, the Rap1 carboxy-terminal domain recruits the Sir2/3/4 and Rif1/2 complexes to repress transcription in addition to promoting Rat1-nuclease-dependent TERRA degradation. At telomeres that contain Y' elements, however, Rap1 represses TERRA through recruitment of Rif1 and Rif2. Our work emphasizes the importance of subtelomeric DNA in the control of telomeric protein composition and telomere transcription.

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Year:  2011        PMID： 21525956      PMCID： PMC3128280          DOI： 10.1038/embor.2011.73

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  34 in total

1.  CpG-island promoters drive transcription of human telomeres.

Authors:  Solomon G Nergadze; Benjamin O Farnung; Harry Wischnewski; Lela Khoriauli; Valerio Vitelli; Raghav Chawla; Elena Giulotto; Claus M Azzalin
Journal:  RNA       Date:  2009-10-22       Impact factor: 4.942

Review 2.  The chromosome ends of Saccharomyces cerevisiae.

Authors:  E J Louis
Journal:  Yeast       Date:  1995-12       Impact factor: 3.239

3.  Identification of a telomere-binding activity from yeast.

Authors:  J Berman; C Y Tachibana; B K Tye
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

Review 4.  RAP1: a protean regulator in yeast.

Authors:  D Shore
Journal:  Trends Genet       Date:  1994-11       Impact factor: 11.639

5.  Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.

Authors:  P Moretti; K Freeman; L Coodly; D Shore
Journal:  Genes Dev       Date:  1994-10-01       Impact factor: 11.361

6.  A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.

Authors:  Yong Chen; Rekha Rai; Zi-Ren Zhou; Junko Kanoh; Cyril Ribeyre; Yuting Yang; Hong Zheng; Pascal Damay; Feng Wang; Hisayo Tsujii; Yasushi Hiraoka; David Shore; Hong-Yu Hu; Sandy Chang; Ming Lei
Journal:  Nat Struct Mol Biol       Date:  2011-01-09       Impact factor: 15.369

Review 7.  TERRA: telomeric repeat-containing RNA.

Authors:  Brian Luke; Joachim Lingner
Journal:  EMBO J       Date:  2009-07-23       Impact factor: 11.598

8.  Distinct differences in chromatin structure at subtelomeric X and Y' elements in budding yeast.

Authors:  Xuefeng Zhu; Claes M Gustafsson
Journal:  PLoS One       Date:  2009-07-23       Impact factor: 3.240

9.  Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.

Authors:  Tonibelle Gatbonton; Maria Imbesi; Melisa Nelson; Joshua M Akey; Douglas M Ruderfer; Leonid Kruglyak; Julian A Simon; Antonio Bedalov
Journal:  PLoS Genet       Date:  2006-03-17       Impact factor: 5.917

10.  The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing.

Authors:  M Cockell; F Palladino; T Laroche; G Kyrion; C Liu; A J Lustig; S M Gasser
Journal:  J Cell Biol       Date:  1995-05       Impact factor: 10.539
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  46 in total

1.  Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α.

Authors:  Nausica Arnoult; Amandine Van Beneden; Anabelle Decottignies
Journal:  Nat Struct Mol Biol       Date:  2012-08-26       Impact factor: 15.369

2.  Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence.

Authors:  Bettina Balk; André Maicher; Martina Dees; Julia Klermund; Sarah Luke-Glaser; Katharina Bender; Brian Luke
Journal:  Nat Struct Mol Biol       Date:  2013-09-08       Impact factor: 15.369

3.  Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase.

Authors:  Tai-Yuan Yu; Yu-wen Kao; Jing-Jer Lin
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-18       Impact factor: 11.205

4.  The Chromatin and Transcriptional Landscape of Native Saccharomyces cerevisiae Telomeres and Subtelomeric Domains.

Authors:  Aisha Ellahi; Deborah M Thurtle; Jasper Rine
Journal:  Genetics       Date:  2015-03-30       Impact factor: 4.562

5.  Paf1 and Ctr9, core components of the PAF1 complex, maintain low levels of telomeric repeat containing RNA.

Authors:  Joana Rodrigues; David Lydall
Journal:  Nucleic Acids Res       Date:  2018-01-25       Impact factor: 16.971

6.  TERRA promotes telomerase-mediated telomere elongation in Schizosaccharomyces pombe.

Authors:  Martin Moravec; Harry Wischnewski; Amadou Bah; Yan Hu; Na Liu; Lorenzo Lafranchi; Megan C King; Claus M Azzalin
Journal:  EMBO Rep       Date:  2016-05-06       Impact factor: 8.807

7.  Induction and relocalization of telomeric repeat-containing RNAs during diauxic shift in budding yeast.

Authors:  Carmina Angelica Perez-Romero; Maxime Lalonde; Pascal Chartrand; Emilio Cusanelli
Journal:  Curr Genet       Date:  2018-03-22       Impact factor: 3.886

8.  Activation of the carbon concentrating mechanism by CO2 deprivation coincides with massive transcriptional restructuring in Chlamydomonas reinhardtii.

Authors:  Andrew J Brueggeman; Dayananda S Gangadharaiah; Matyas F Cserhati; David Casero; Donald P Weeks; Istvan Ladunga
Journal:  Plant Cell       Date:  2012-05-25       Impact factor: 11.277

9.  Deletion of the major peroxiredoxin Tsa1 alters telomere length homeostasis.

Authors:  Jian Lu; Haritha Vallabhaneni; Jinhu Yin; Yie Liu
Journal:  Aging Cell       Date:  2013-05-15       Impact factor: 9.304

Review 10.  The Telomere Paradox: Stable Genome Preservation with Rapidly Evolving Proteins.

Authors:  Bastien Saint-Leandre; Mia T Levine
Journal:  Trends Genet       Date:  2020-02-12       Impact factor: 11.639
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