OBJECTIVE: To determine the effects and safety of dioctahedral smectite (DS) on the duration of acute watery diarrhea in children. METHODS: A Randomized, open labeled, clinical controlled trial in a tertiary care hospital outpatient department (OPD) and emergency department. Participants were one hundred and seventeen children without any chronic illness between 2 and 5 years presenting to OPD, having acute watery diarrhea for <48 h with mild to moderate dehydration, not on antibiotics and requiring oral rehydration therapy. Intervention done was DS with a dose of 1.5 g thrice daily. RESULTS:Freshly dissolved DS in a dose of 1.5 g thrice daily for 5 days significantly shortened the duration of acute watery diarrhea in children aged 2-5 years. There were no adverse effects on the use of DS. DS was acceptable to the children, and its administration was not accompanied with any side effects. CONCLUSION:DS reduces the duration of diarrhea in Indian children and prevents a prolonged course, and therefore, may consistently reduce the costs in treatment of acute watery diarrhea.
RCT Entities:
OBJECTIVE: To determine the effects and safety of dioctahedral smectite (DS) on the duration of acute watery diarrhea in children. METHODS: A Randomized, open labeled, clinical controlled trial in a tertiary care hospital outpatient department (OPD) and emergency department. Participants were one hundred and seventeen children without any chronic illness between 2 and 5 years presenting to OPD, having acute watery diarrhea for <48 h with mild to moderate dehydration, not on antibiotics and requiring oral rehydration therapy. Intervention done was DS with a dose of 1.5 g thrice daily. RESULTS: Freshly dissolved DS in a dose of 1.5 g thrice daily for 5 days significantly shortened the duration of acute watery diarrhea in children aged 2-5 years. There were no adverse effects on the use of DS. DS was acceptable to the children, and its administration was not accompanied with any side effects. CONCLUSION:DS reduces the duration of diarrhea in Indian children and prevents a prolonged course, and therefore, may consistently reduce the costs in treatment of acute watery diarrhea.
Authors: Katherine E Zychowski; Sarah E Elmore; Kristal A Rychlik; Hoai J Ly; Felipe Pierezan; Anitha Isaiah; Jan S Suchodolski; Aline Rodrigues Hoffmann; Amelia A Romoser; Timothy D Phillips Journal: Dig Dis Sci Date: 2014-09-21 Impact factor: 3.199