BACKGROUND: Coronary artery calcification (CAC) is an independent and incremental risk marker. This marker has previously not been compared to the HeartScore risk model. DESIGN: A random sample of 1825 citizens (men and women, 50 or 60 years of age) was invited for screening. METHODS: Using the HeartScore model, the 10-year risk of fatal cardiovascular events based on gender, age, smoking, systolic blood pressure, and total cholesterol was estimated. A low risk was defined as <5%. The CAC score was calculated from a non-contrast enhanced cardiac-CT scan and given in Agatston U. RESULTS: A total of 1257 (69%) of the invited subjects were interested in the screening. Due to previous cardiovascular disease or diabetes mellitus, 101 were excluded. Of the remaining 1156, 47% were men and 53% women; one half were 50 years old and the other half 60 years old. A low HeartScore was found in 901 of which 334 (37%) had CAC. A high HeartScore was recorded in 251 of which 80 (32%) did not have any CAC. High HeartScores and CAC were significantly more common in males than females. CONCLUSIONS: CAC is common in healthy middle-aged Danes with a low HeartScore, and, on the contrary, high-risk subjects very frequently do not have CAC. The therapeutic and prognostic implications of these observations remain to be clarified.
BACKGROUND:Coronary artery calcification (CAC) is an independent and incremental risk marker. This marker has previously not been compared to the HeartScore risk model. DESIGN: A random sample of 1825 citizens (men and women, 50 or 60 years of age) was invited for screening. METHODS: Using the HeartScore model, the 10-year risk of fatal cardiovascular events based on gender, age, smoking, systolic blood pressure, and total cholesterol was estimated. A low risk was defined as <5%. The CAC score was calculated from a non-contrast enhanced cardiac-CT scan and given in Agatston U. RESULTS: A total of 1257 (69%) of the invited subjects were interested in the screening. Due to previous cardiovascular disease or diabetes mellitus, 101 were excluded. Of the remaining 1156, 47% were men and 53% women; one half were 50 years old and the other half 60 years old. A low HeartScore was found in 901 of which 334 (37%) had CAC. A high HeartScore was recorded in 251 of which 80 (32%) did not have any CAC. High HeartScores and CAC were significantly more common in males than females. CONCLUSIONS: CAC is common in healthy middle-aged Danes with a low HeartScore, and, on the contrary, high-risk subjects very frequently do not have CAC. The therapeutic and prognostic implications of these observations remain to be clarified.
Authors: M L Nielsen; M Pareek; O Gerke; S Z Diederichsen; S V Greve; M K Blicher; N P R Sand; H Mickley; A C P Diederichsen; M H Olsen Journal: J Hum Hypertens Date: 2014-10-02 Impact factor: 3.012
Authors: Ida S Bjerrum; Niels P Rønnow Sand; Mikael K Poulsen; Bjarne L Nørgaard; Johannes J Sidelmann; Allan Johansen; Hans Mickley; Axel C P Diederichsen Journal: Int J Cardiovasc Imaging Date: 2012-07-05 Impact factor: 2.357
Authors: Natasha Barascuk; Federica Genovese; Lise Larsen; Inger Byrjalsen; Qinlong Zheng; Shu Sun; Susanne Hosbond; Tina S Poulsen; Axel Diederichsen; Jesper M Jensen; Hans Mickley; Thomas C Register; Lars M Rasmussen; Diana J Leeming; Claus Christiansen; Morten A Karsdal Journal: Int J Clin Exp Med Date: 2013-03-21
Authors: Helene Skjøt-Arkil; Rikke E Clausen; Lars M Rasmussen; Wanchun Wang; Yaguo Wang; Qinlong Zheng; Hans Mickley; Lotte Saaby; Axel C P Diederichsen; Jess Lambrechtsen; Fernando J Martinez; Cory M Hogaboam; Meilan Han; Martin R Larsen; Arkadiusz Nawrocki; Ben Vainer; Dorrit Krustrup; Marina Bjørling-Poulsen; Morten A Karsdal; Diana J Leeming Journal: PLoS One Date: 2013-06-21 Impact factor: 3.240
Authors: Alexandra Scholze; Else-Marie Bladbjerg; Johannes J Sidelmann; Axel C P Diederichsen; Hans Mickley; Mads Nybo; W Scott Argraves; Peter Marckmann; Lars M Rasmussen Journal: Cardiovasc Diabetol Date: 2013-01-07 Impact factor: 9.951
Authors: Helle Wallach-Kildemoes; Finn Diderichsen; Allan Krasnik; Theis Lange; Morten Andersen Journal: BMC Public Health Date: 2012-08-04 Impact factor: 3.295