OBJECTIVES: To determine the feasibility of implementing a broadband screen at the 1-year check-up to detect cases of autism spectrum disorders (ASD), language delay (LD), and developmental delay (DD). STUDY DESIGN: The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist was distributed at every 1-year pediatric check-up; 137 pediatricians and 225 infants participated. Screens were scored immediately, and failures referred for further evaluation. RESULTS: Pediatricians screened 10 479 infants at the 1-year check-up; 184 infants who failed the screen were evaluated and tracked. To date, 32 infants received a provisional or final diagnosis of ASD, 56 of LD, nine of DD, and 36 of "other." Five infants who initially tested positive for ASD no longer met criteria at follow-up. The remainder of the sample was false positive results. Positive predictive value was estimated to be .75. CONCLUSIONS: The 1-Year Well-Baby Check-Up Approach shows promise as a simple mechanism to detect cases of ASD, LD, and DD at 1 year. This procedure offers an alternative to the baby sibling design as a mechanism to study autism prospectively, the results of which will enrich our understanding of autism at an early age.
OBJECTIVES: To determine the feasibility of implementing a broadband screen at the 1-year check-up to detect cases of autism spectrum disorders (ASD), language delay (LD), and developmental delay (DD). STUDY DESIGN: The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist was distributed at every 1-year pediatric check-up; 137 pediatricians and 225 infants participated. Screens were scored immediately, and failures referred for further evaluation. RESULTS: Pediatricians screened 10 479 infants at the 1-year check-up; 184 infants who failed the screen were evaluated and tracked. To date, 32 infants received a provisional or final diagnosis of ASD, 56 of LD, nine of DD, and 36 of "other." Five infants who initially tested positive for ASD no longer met criteria at follow-up. The remainder of the sample was false positive results. Positive predictive value was estimated to be .75. CONCLUSIONS: The 1-Year Well-Baby Check-Up Approach shows promise as a simple mechanism to detect cases of ASD, LD, and DD at 1 year. This procedure offers an alternative to the baby sibling design as a mechanism to study autism prospectively, the results of which will enrich our understanding of autism at an early age.
Authors: A Cox; K Klein; T Charman; G Baird; S Baron-Cohen; J Swettenham; A Drew; S Wheelwright Journal: J Child Psychol Psychiatry Date: 1999-07 Impact factor: 8.982
Authors: L B Jorde; S J Hasstedt; E R Ritvo; A Mason-Brothers; B J Freeman; C Pingree; W M McMahon; B Petersen; W R Jenson; A Mo Journal: Am J Hum Genet Date: 1991-11 Impact factor: 11.025
Authors: Linda R Watson; Elizabeth R Crais; Grace T Baranek; Lauren Turner-Brown; John Sideris; Linn Wakeford; Jessica Kinard; J Steven Reznick; Katrina L Martin; Sallie W Nowell Journal: J Autism Dev Disord Date: 2017-11
Authors: Anne M Roux; Patricia Herrera; Cheryl M Wold; Margaret C Dunkle; Frances P Glascoe; Paul T Shattuck Journal: Am J Prev Med Date: 2012-12 Impact factor: 5.043