Literature DB >> 21523635

[Functional organ preservation in laryngeal and hypopharyngeal cancer].

P Ambrosch1, A Fazel.   

Abstract

The principles of open vs. laser microsurgical approaches for partial resections of the larynx are described, oncological as well as functional results discussed and corresponding outcomes following primary radiotherapy are opposed. Over the last decade, the endoscopic partial resection of the larynx has developed to an accepted approach in the treatment of early glottic and supraglottic carcinomas thus leading to a remarkable decline in the use of open surgery. Comparing the various surgical approaches of laryngeal partial resections, the oncological outcome of the patients, as far as survival and organ preservation are concerned, are comparable, whereas functional results of the endoscopic procedures are superior with less morbidity. The surgical procedures put together, are all superior to radiotherapy concerning organ preservation. Transoral laser microsurgery has been used successfully for vocal cord carcinomas with impaired mobility or fixation of the vocal cord, supraglottic carcinomas with infiltration of the pre- and/or paraglottic space as well as for selected hypopharyngeal carcinomas. It has been well documented that laser microsurgery achieves good oncological as well as functional results with reasonable morbidity. However, patients with those tumours have been successfully treated by open partial resections of the larynx at medical centres with appropriate expertise. The initially enthusiastic assessment of study results concerning the efficacy of various protocols of chemoradiation with the intent of organ preservation for laryngeal and hypopharyngeal carcinomas are judged more cautious, today, due to recent reports of rather high rates of late toxicity complications. © Georg Thieme Verlag KG Stuttgart · New York.

Entities:  

Mesh:

Year:  2011        PMID: 21523635     DOI: 10.1055/s-0030-1270449

Source DB:  PubMed          Journal:  Laryngorhinootologie        ISSN: 0935-8943            Impact factor:   1.057


  5 in total

1.  [Recent advances in the treatment of laryngeal and hypopharyngeal carcinoma].

Authors:  H E Eckel
Journal:  HNO       Date:  2012-01       Impact factor: 1.284

2.  Prognostic factors for local control in patients receiving radiation therapy for early glottic cancer: anterior commissure involvement and effect of chemoradiotherapy.

Authors:  Yosuke Kitani; Akira Kubota; Madoka Furukawa; Kaname Sato
Journal:  Eur Arch Otorhinolaryngol       Date:  2015-03-01       Impact factor: 2.503

3.  Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes.

Authors:  Daniela Alterio; Simona Marani; Valeria Zurlo; Stefano Filippo Zorzi; Annamaria Ferrari; Stefania Volpe; Francesco Bandi; Sabrina Vigorito; Maria Giulia Vincini; Sara Gandini; Aurora Gaeta; Cristiana Iuliana Fodor; Alessia Casbarra; Mattia Zaffaroni; Anna Starzyńska; Liliana Belgioia; Mohssen Ansarin; Cynthia Aristei; Barbara Alicja Jereczek-Fossa
Journal:  Cancers (Basel)       Date:  2022-05-24       Impact factor: 6.575

Review 4.  Evidence and evidence gaps of laryngeal cancer surgery.

Authors:  Susanne Wiegand
Journal:  GMS Curr Top Otorhinolaryngol Head Neck Surg       Date:  2016-12-15

5.  Preservation of organ function in head and neck cancer.

Authors:  Uta Tschiesner
Journal:  GMS Curr Top Otorhinolaryngol Head Neck Surg       Date:  2012-12-20
  5 in total

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