Yuri G Anissimov1, Michael Stephen Roberts. 1. School of Biomolecular and Physical Sciences, Griffith University, Gold Coast, Queensland 4222, Australia. Y.Anissimov@Griffith.edu.au
Abstract
PURPOSE: To model and interpret drug distribution in the dermis and underlying tissues after topical application which is relevant to the treatment of local conditions. METHODS: We created a new physiological pharmacokinetic model to describe the effect of blood flow, blood protein binding and dermal binding on the rate and depth of penetration of topical drugs into the underlying skin. We used this model to interpret literature in vivo human biopsy data on dermal drug concentration at various depths in the dermis after topical application of six substances. This interpretation was facilitated by our in vitro human dermal penetration studies in which dermal diffusion coefficient and binding were estimated. RESULTS: The model shows that dermal diffusion alone cannot explain the in vivo data, and blood and/or lymphatic transport to deep tissues must be present for almost all of the drugs tested. CONCLUSION: Topical drug delivery systems for deeper tissue delivery should recognise that blood/lymphatic transport may dominate over dermal diffusion for certain compounds.
PURPOSE: To model and interpret drug distribution in the dermis and underlying tissues after topical application which is relevant to the treatment of local conditions. METHODS: We created a new physiological pharmacokinetic model to describe the effect of blood flow, blood protein binding and dermal binding on the rate and depth of penetration of topical drugs into the underlying skin. We used this model to interpret literature in vivo human biopsy data on dermal drug concentration at various depths in the dermis after topical application of six substances. This interpretation was facilitated by our in vitro human dermal penetration studies in which dermal diffusion coefficient and binding were estimated. RESULTS: The model shows that dermal diffusion alone cannot explain the in vivo data, and blood and/or lymphatic transport to deep tissues must be present for almost all of the drugs tested. CONCLUSION: Topical drug delivery systems for deeper tissue delivery should recognise that blood/lymphatic transport may dominate over dermal diffusion for certain compounds.
Authors: Terri D LaCount; Qian Zhang; Jinsong Hao; Priyanka Ghosh; Sam G Raney; Arjang Talattof; Gerald B Kasting; S Kevin Li Journal: AAPS J Date: 2020-05-10 Impact factor: 4.009
Authors: Manfred Bodenlenz; Christian Dragatin; Lisa Liebenberger; Bernd Tschapeller; Beate Boulgaropoulos; Thomas Augustin; Reingard Raml; Christina Gatschelhofer; Nathalie Wagner; Khaled Benkali; Francois Rony; Thomas Pieber; Frank Sinner Journal: Pharm Res Date: 2016-06-06 Impact factor: 4.200