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Literature DB >> 21523396

Cell and gene therapy for bone repair.

Abstract

Improving bone repair remains an important and challenging issue. Therapeutic approaches to amplify osteogenic cell pool or function include cell and gene therapies. We identified genes that promote human mesenchymal cell differentiation and bone formation. Targeting these or other genes may improve the efficacy of cell therapy for bone repair.

Entities: Species

Mesh：

Year: 2011 PMID： 21523396 DOI： 10.1007/s00198-011-1615-0

Source DB: PubMed Journal: Osteoporos Int ISSN： 0937-941X Impact factor: 4.507

20 in total

1. Tissue-engineered bone regeneration.

Authors: H Petite; V Viateau; W Bensaïd; A Meunier; C de Pollak; M Bourguignon; K Oudina; L Sedel; G Guillemin
Journal: Nat Biotechnol Date: 2000-09 Impact factor: 54.908

2. Treatment of osteonecrosis with autologous bone marrow grafting.

Authors: Philippe Hernigou; Françoise Beaujean
Journal: Clin Orthop Relat Res Date: 2002-12 Impact factor: 4.176

Review 3. Protein- and gene-based tissue engineering in bone repair.

Authors: Michelle D Kofron; Xudong Li; Cato T Laurencin
Journal: Curr Opin Biotechnol Date: 2004-10 Impact factor: 9.740

Review 4. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views.

Authors: Donald G Phinney; Darwin J Prockop
Journal: Stem Cells Date: 2007-09-27 Impact factor: 6.277

Review 5. Mesenchymal stem cells in bone and cartilage repair: current status.

Authors: Jean-Thomas Vilquin; Philippe Rosset
Journal: Regen Med Date: 2006-07 Impact factor: 3.806

6. Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: a combined gene therapy-cell transplantation approach.

Authors: Ehsan Jabbarzadeh; Trevor Starnes; Yusuf M Khan; Tao Jiang; Anthony J Wirtel; Meng Deng; Qing Lv; Lakshmi S Nair; Steven B Doty; Cato T Laurencin
Journal: Proc Natl Acad Sci U S A Date: 2008-08-04 Impact factor: 11.205

3. Effect of cyclic mechanical stimulation on the expression of osteogenesis genes in human intraoral mesenchymal stromal and progenitor cells.

Authors: Birgit Lohberger; Heike Kaltenegger; Nicole Stuendl; Michael Payer; Beate Rinner; Andreas Leithner
Journal: Biomed Res Int Date: 2014-04-07 Impact factor: 3.411

3 in total

Cell and gene therapy for bone repair.

1. Tissue-engineered bone regeneration.

2. Treatment of osteonecrosis with autologous bone marrow grafting.

Review 3. Protein- and gene-based tissue engineering in bone repair.

Review 4. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views.

Review 5. Mesenchymal stem cells in bone and cartilage repair: current status.

6. Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: a combined gene therapy-cell transplantation approach.

Review 7. Circulating endothelial/skeletal progenitor cells for bone regeneration and healing.

8. Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells.

Review 9. Human mesenchymal stem cells: from basic biology to clinical applications.

10. Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis.

Review 1. Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts.

Review 2. The Utility of Allograft Mesenchymal Stem Cells for Spine Fusion: A Literature Review.

3. Effect of cyclic mechanical stimulation on the expression of osteogenesis genes in human intraoral mesenchymal stromal and progenitor cells.