Matthew C Riddle1. 1. Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health & Science University, Portland, Oregon 97239-3098, USA. riddle@ohsu.edu
Abstract
PURPOSE OF REVIEW: Diabetes mellitus is associated with several-fold increased risk of cardiovascular events, including death, yet whether treatment of hyperglycemia can reduce this risk remains controversial. RECENT FINDINGS: Epidemiologic associations between hyperglycemia and cardiovascular risk have been confirmed and extended to levels below those diagnostic of diabetes. Long-term follow-up of treatment early in diabetes suggests benefits may lag 10 years or more after initiation of treatment. Intensive glycemic treatment of high-risk persons with current methods may increase short-term mortality. SUMMARY: Further analyses of existing data to define high-risk and lower-risk subgroups of patients may allow revision of treatment guidelines. Future studies may begin early in diabetes, require long-term follow-up, and use improved methods of treatment.
PURPOSE OF REVIEW: Diabetes mellitus is associated with several-fold increased risk of cardiovascular events, including death, yet whether treatment of hyperglycemia can reduce this risk remains controversial. RECENT FINDINGS: Epidemiologic associations between hyperglycemia and cardiovascular risk have been confirmed and extended to levels below those diagnostic of diabetes. Long-term follow-up of treatment early in diabetes suggests benefits may lag 10 years or more after initiation of treatment. Intensive glycemic treatment of high-risk persons with current methods may increase short-term mortality. SUMMARY: Further analyses of existing data to define high-risk and lower-risk subgroups of patients may allow revision of treatment guidelines. Future studies may begin early in diabetes, require long-term follow-up, and use improved methods of treatment.
Authors: Marie F A Cutiongco; Bryan M X Chua; Dawn J H Neo; Muhammad Rizwan; Evelyn K F Yim Journal: Biomaterials Date: 2017-10-25 Impact factor: 12.479
Authors: Anne Pernille Ofstad; Geir Reinvik Ulimoen; Elsa Orvik; Kåre Inge Birkeland; Lars L Gullestad; Morten Wang Fagerland; Odd Erik Johansen Journal: J Int Med Res Date: 2017-06-19 Impact factor: 1.671