Literature DB >> 21521941

Regulation of autophagy by lysosomal positioning.

Viktor I Korolchuk1, David C Rubinsztein.   

Abstract

The mammalian target of rapamycin (mTOR) is a well-conserved negative regulator of autophagy. Here we review our recent data describing how lysosomal positioning influences and coordinates mTOR activity, autophagosome biogenesis and autophagosome-lysosome fusion. In this way, lysosomal positioning regulates many diverse cellular responses to starvation and subsequent nutrient replenishment.

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Year:  2011        PMID： 21521941      PMCID： PMC3149695          DOI： 10.4161/auto.7.8.15862

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  1 in total

1.  Lysosomal positioning coordinates cellular nutrient responses.

Authors:  Viktor I Korolchuk; Shinji Saiki; Maike Lichtenberg; Farah H Siddiqi; Esteban A Roberts; Sara Imarisio; Luca Jahreiss; Sovan Sarkar; Marie Futter; Fiona M Menzies; Cahir J O'Kane; Vojo Deretic; David C Rubinsztein
Journal:  Nat Cell Biol       Date:  2011-03-13       Impact factor: 28.824
  1 in total
  53 in total

1.  Mycobacterial induction of autophagy varies by species and occurs independently of mammalian target of rapamycin inhibition.

Authors:  Alfred J Zullo; Sunhee Lee
Journal:  J Biol Chem       Date:  2012-01-24       Impact factor: 5.157

2.  Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport.

Authors:  Nava Zaarur; Anatoli B Meriin; Eloy Bejarano; Xiaobin Xu; Vladimir L Gabai; Ana Maria Cuervo; Michael Y Sherman
Journal:  Mol Cell Biol       Date:  2014-01-27       Impact factor: 4.272

Review 3.  LRRK2 pathobiology in Parkinson's disease.

Authors:  Ian Martin; Jungwoo Wren Kim; Valina L Dawson; Ted M Dawson
Journal:  J Neurochem       Date:  2014-10-10       Impact factor: 5.372

4.  Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation.

Authors:  Yair Botbol; Bindi Patel; Fernando Macian
Journal:  Autophagy       Date:  2015       Impact factor: 16.016

5.  Biphasic regulation of lysosomal exocytosis by oxidative stress.

Authors:  Sreeram Ravi; Karina A Peña; Charleen T Chu; Kirill Kiselyov
Journal:  Cell Calcium       Date:  2016-08-29       Impact factor: 6.817

Review 6.  Oxidative and nitrative stress in neurodegeneration.

Authors:  Catherine A Cobb; Marsha P Cole
Journal:  Neurobiol Dis       Date:  2015-05-27       Impact factor: 5.996

7.  Autophagy involving age-related cognitive behavior and hippocampus injury is modulated by different caloric intake in mice.

Authors:  Wen Dong; Rong Wang; Li-Na Ma; Bao-Lei Xu; Jing-Shuang Zhang; Zhi-Wei Zhao; Yu-Lan Wang; Xu Zhang
Journal:  Int J Clin Exp Med       Date:  2015-07-15

8.  Characterization of the endolysosomal system in human chordoma cell lines: is there a role of lysosomes in chemoresistance of this rare bone tumor?

Authors:  Dagmar Kolb-Lenz; Robert Fuchs; Birgit Lohberger; Ellen Heitzer; Katharina Meditz; Dominique Pernitsch; Elisabeth Pritz; Andrea Groselj-Strele; Andreas Leithner; Bernadette Liegl-Atzwanger; Beate Rinner
Journal:  Histochem Cell Biol       Date:  2018-05-03       Impact factor: 4.304

9.  Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease.

Authors:  Sierra Lavoy; Vinita G Chittoor-Vinod; Clement Y Chow; Ian Martin
Journal:  Genetics       Date:  2018-06-15       Impact factor: 4.562

10.  The microtubule-associated protein EB1 links AIM2 inflammasomes with autophagy-dependent secretion.

Authors:  Li-Jie Wang; Hsin-Yi Huang; Meng-Pin Huang; Willisa Liou; Ya-Ting Chang; Chih-Ching Wu; David M Ojcius; Yu-Sun Chang
Journal:  J Biol Chem       Date:  2014-08-27       Impact factor: 5.157
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