Literature DB >> 21521931

Na+/Ca2+ exchanger inhibitors inhibit neurite outgrowth in PC12 cells.

Toru Oda1, Toshiaki Kume, Yasuhiko Izumi, Kumatoshi Ishihara, Hachiro Sugmimoto, Akinori Akaike.   

Abstract

To elucidate the role of Na(+)/Ca(2+) exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells. KB-R7943 and 3',4'-dichlorobenzamil, NCX inhibitors, inhibited the neurite outgrowth caused by nerve growth factor (NGF). NCX inhibitors inhibited the neurite outgrowth caused by dibutylyl cAMP, which rapidly reorganizes the cytoskeleton. KB-R7943 inhibited the neurite outgrowth caused by Y-27632, an inhibitor of Rho kinase (ROCK) that regulates actin. However, NCX inhibitors did not inhibit NGF-induced phosphorylation of extracellular signal-regulated kinase. These results suggest that NCX inhibitor affects downstream of the Rho-ROCK signal transduction pathways in neurite outgrowth.

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Year:  2011        PMID： 21521931     DOI： 10.1254/jphs.11011sc

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  4 in total

1.  Roles of Na(+)/Ca(2+) exchanger isoforms NCX1 and NCX2 in motility in mouse ileum.

Authors:  Kazuhiro Nishiyama; Yasu-Taka Azuma; Ai Morioka; Natsuho Yoshida; Midori Teramoto; Kohta Tanioka; Satomi Kita; Satomi Hayashi; Hidemitsu Nakajima; Takahiro Iwamoto; Tadayoshi Takeuchi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-07-14       Impact factor: 3.000

2.  Cortex Mori Radicis Extract induces neurite outgrowth in PC12 cells activating ERK signaling pathway via inhibiting Ca(2+) influx.

Authors:  Nina Yin; Xiaoping Hong; Yongming Han; Yanjun Duan; Yanhong Zhang; Zebin Chen
Journal:  Int J Clin Exp Med       Date:  2015-04-15

3.  Involvement of the Na+/Ca2+ exchanger isoform 1 (NCX1) in neuronal growth factor (NGF)-induced neuronal differentiation through Ca2+-dependent Akt phosphorylation.

Authors:  Agnese Secondo; Alba Esposito; Rossana Sirabella; Francesca Boscia; Anna Pannaccione; Pasquale Molinaro; Maria Cantile; Roselia Ciccone; Maria Josè Sisalli; Antonella Scorziello; Gianfranco Di Renzo; Lucio Annunziato
Journal:  J Biol Chem       Date:  2014-11-21       Impact factor: 5.157

4.  A high-content phenotypic screen reveals the disruptive potency of quinacrine and 3',4'-dichlorobenzamil on the digestive vacuole of Plasmodium falciparum.

Authors:  Yan Quan Lee; Amanda S P Goh; Jun Hong Ch'ng; François H Nosten; Peter Rainer Preiser; Shazib Pervaiz; Sanjiv Kumar Yadav; Kevin S W Tan
Journal:  Antimicrob Agents Chemother       Date:  2013-11-11       Impact factor: 5.191
  4 in total

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