OBJECTIVE: Prolactin (PRL) is involved in immune regulation and may contribute to an atherogenic phenotype. Previous results on the association of PRL with inflammatory biomarkers have been conflicting and limited by small patient studies. Therefore, we used data from a large population-based sample to assess the cross-sectional associations between serum PRL concentration and high-sensitivity C-reactive protein (hsCRP), fibrinogen, interleukin-6 (IL-6), and white blood cell (WBC) count. DESIGN AND POPULATION: From the population-based Study of Health in Pomerania (SHIP), a total of 3744 subjects were available for the present analyses. METHODS AND MEASUREMENTS: PRL and inflammatory biomarkers were measured. Linear and logistic regression models adjusted for age, sex, body-mass-index, total cholesterol and glucose were analysed. RESULTS: Multivariable linear regression models revealed a positive association of PRL with WBC. Multivariable logistic regression analyses showed a significant association of PRL with increased IL-6 in non-smokers [highest vs lowest quintile: odds ratio 1·69 (95% confidence interval 1·10-2·58), P = 0·02] and smokers [OR 2·06 (95%-CI 1·10-3·89), P = 0·02]. Similar results were found for WBC in non-smokers [highest vs lowest quintile: OR 2·09 (95%-CI 1·21-3·61), P = 0·01)] but not in smokers. Linear and logistic regression analyses revealed no significant associations of PRL with hsCRP or fibrinogen. CONCLUSIONS: Serum PRL concentrations are associated with inflammatory biomarkers including IL-6 and WBC, but not hsCRP or fibrinogen. The suggested role of PRL in inflammation needs further investigation in future prospective studies.
OBJECTIVE:Prolactin (PRL) is involved in immune regulation and may contribute to an atherogenic phenotype. Previous results on the association of PRL with inflammatory biomarkers have been conflicting and limited by small patient studies. Therefore, we used data from a large population-based sample to assess the cross-sectional associations between serum PRL concentration and high-sensitivity C-reactive protein (hsCRP), fibrinogen, interleukin-6 (IL-6), and white blood cell (WBC) count. DESIGN AND POPULATION: From the population-based Study of Health in Pomerania (SHIP), a total of 3744 subjects were available for the present analyses. METHODS AND MEASUREMENTS: PRL and inflammatory biomarkers were measured. Linear and logistic regression models adjusted for age, sex, body-mass-index, total cholesterol and glucose were analysed. RESULTS: Multivariable linear regression models revealed a positive association of PRL with WBC. Multivariable logistic regression analyses showed a significant association of PRL with increased IL-6 in non-smokers [highest vs lowest quintile: odds ratio 1·69 (95% confidence interval 1·10-2·58), P = 0·02] and smokers [OR 2·06 (95%-CI 1·10-3·89), P = 0·02]. Similar results were found for WBC in non-smokers [highest vs lowest quintile: OR 2·09 (95%-CI 1·21-3·61), P = 0·01)] but not in smokers. Linear and logistic regression analyses revealed no significant associations of PRL with hsCRP or fibrinogen. CONCLUSIONS: Serum PRL concentrations are associated with inflammatory biomarkers including IL-6 and WBC, but not hsCRP or fibrinogen. The suggested role of PRL in inflammation needs further investigation in future prospective studies.
Authors: G Georgiopoulos; I Lambrinoudaki; F Athanasouli; E Armeni; A Koliviras; A Augoulea; D Rizos; C Papamichael; A Protogerou; K Stellos; K Stamatelopoulos Journal: J Hum Hypertens Date: 2017-03-23 Impact factor: 3.012
Authors: Lisa Balbach; Henri Wallaschofski; Henry Völzke; Matthias Nauck; Marcus Dörr; Robin Haring Journal: BMC Endocr Disord Date: 2013-03-21 Impact factor: 2.763
Authors: Hans J Grabe; Heinrich Assel; Thomas Bahls; Marcus Dörr; Karlhans Endlich; Nicole Endlich; Pia Erdmann; Ralf Ewert; Stephan B Felix; Beate Fiene; Tobias Fischer; Steffen Flessa; Nele Friedrich; Mariacarla Gadebusch-Bondio; Manuela Gesell Salazar; Elke Hammer; Robin Haring; Christoph Havemann; Michael Hecker; Wolfgang Hoffmann; Birte Holtfreter; Tim Kacprowski; Kathleen Klein; Thomas Kocher; Holger Kock; Janina Krafczyk; Jana Kuhn; Martin Langanke; Uwe Lendeckel; Markus M Lerch; Wolfgang Lieb; Roberto Lorbeer; Julia Mayerle; Konrad Meissner; Henriette Meyer zu Schwabedissen; Matthias Nauck; Konrad Ott; Wolfgang Rathmann; Rainer Rettig; Claudia Richardt; Karen Saljé; Ulf Schminke; Andrea Schulz; Matthias Schwab; Werner Siegmund; Sylvia Stracke; Karsten Suhre; Marius Ueffing; Saskia Ungerer; Uwe Völker; Henry Völzke; Henri Wallaschofski; Vivian Werner; Marek T Zygmunt; Heyo K Kroemer Journal: J Transl Med Date: 2014-05-23 Impact factor: 5.531