Literature DB >> 21521156

Nitroimidazoles as anti-tumor agents.

Kai Liu1, Hai-Liang Zhu.   

Abstract

At present cancer treatment is still a confusing problem. Great progress has been made in anti-tumor agents since a series of small molecules are approved by FDA as anti-tumor drugs. Nitroimidazoles is a kind of radiosensitizer with multiple bioactivities used in cancer treatment since 1950s. In this review, we focus on the development of nitroimidazoles as radiosensitizer, bio-reductive prodrug and other types of anti-tumor agents for cancer therapy, and the mechanism of acting as anti-tumor agents. Finally, we also discuss the prospect and developmental trend of nitroimidazoles as anti-tumor agents.

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Year:  2011        PMID： 21521156     DOI： 10.2174/187152011796817664

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


  4 in total

Review 1.  Hypoxia-active nanoparticles used in tumor theranostic.

Authors:  Yaqin Wang; Wenting Shang; Meng Niu; Jie Tian; Ke Xu
Journal:  Int J Nanomedicine       Date:  2019-05-22

2.  Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series.

Authors:  Ashok Aspatwar; Nanda Kumar Parvathaneni; Harlan Barker; Emilie Anduran; Claudiu T Supuran; Ludwig Dubois; Philippe Lambin; Seppo Parkkila; Jean-Yves Winum
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

3.  Synthesis and Biological Evaluation of Iodoglucoazomycin (I-GAZ), an Azomycin-Glucose Adduct with Putative Applications in Diagnostic Imaging and Radiotherapy of Hypoxic Tumors.

Authors:  Piyush Kumar; Hassan R H Elsaidi; Bohdarianna Zorniak; Evelyn Laurens; Jennifer Yang; Veena Bacchu; Monica Wang; Leonard I Wiebe
Journal:  ChemMedChem       Date:  2016-07-05       Impact factor: 3.466

4.  Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes.

Authors:  Ashok Aspatwar; Holger M Becker; Nanda Kumar Parvathaneni; Milka Hammaren; Aleksandra Svorjova; Harlan Barker; Claudiu T Supuran; Ludwig Dubois; Philippe Lambin; Mataleena Parikka; Seppo Parkkila; Jean-Yves Winum
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051
  4 in total

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