Literature DB >> 21520849

A hybrid approach for rapid, accurate, and direct kilovoltage radiation dose calculations in CT voxel space.

Alexei Kouznetsov1, Mauro Tambasco.   

Abstract

PURPOSE: To develop and validate a fast and accurate method that uses computed tomography (CT) voxel data to estimate absorbed radiation dose at a point of interest (POI) or series of POIs from a kilovoltage (kV) imaging procedure.
METHODS: The authors developed an approach that computes absorbed radiation dose at a POI by numerically evaluating the linear Boltzmann transport equation (LBTE) using a combination of deterministic and Monte Carlo (MC) techniques. This hybrid approach accounts for material heterogeneity with a level of accuracy comparable to the general MC algorithms. Also, the dose at a POI is computed within seconds using the Intel Core i7 CPU 920 2.67 GHz quad core architecture, and the calculations are performed using CT voxel data, making it flexible and feasible for clinical applications. To validate the method, the authors constructed and acquired a CT scan of a heterogeneous block phantom consisting of a succession of slab densities: Tissue (1.29 cm), bone (2.42 cm), lung (4.84 cm), bone (1.37 cm), and tissue (4.84 cm). Using the hybrid transport method, the authors computed the absorbed doses at a set of points along the central axis and x direction of the phantom for an isotropic 125 kVp photon spectral point source located along the central axis 92.7 cm above the phantom surface. The accuracy of the results was compared to those computed with MCNP, which was cross-validated with EGSnrc, and served as the benchmark for validation.
RESULTS: The error in the depth dose ranged from -1.45% to +1.39% with a mean and standard deviation of -0.12% and 0.66%, respectively. The error in the x profile ranged from -1.3% to +0.9%, with standard deviations of -0.3% and 0.5%, respectively. The number of photons required to achieve these results was 1 x 10(6).
CONCLUSIONS: The voxel-based hybrid method evaluates the LBTE rapidly and accurately to estimate the absorbed x-ray dose at any POI or series of POIs from a kV imaging procedure.

Mesh:

Year:  2011        PMID: 21520849     DOI: 10.1118/1.3555038

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  9 in total

1.  Quantitative percussion diagnostics and bone density analysis of the implant-bone interface in a pre- and postmortem human subject.

Authors:  Cherilyn G Sheets; Dee Dee Hui; Vaibhav Bajaj; James C Earthman
Journal:  Int J Oral Maxillofac Implants       Date:  2013 Nov-Dec       Impact factor: 2.804

2.  The potential impact of ultrathin filter design on dosimetry and relative biological effectiveness in modern image-guided small animal irradiators.

Authors:  Yannick Poirier; Christopher Daniel Johnstone; Charles Kirkby
Journal:  Br J Radiol       Date:  2018-11-15       Impact factor: 3.039

3.  Chronic Corticosterone Treatment During Adolescence Has Significant Effects on Metabolism and Skeletal Development in Male C57BL6/N Mice.

Authors:  Scott A Kinlein; Ziasmin Shahanoor; Russell D Romeo; Ilia N Karatsoreos
Journal:  Endocrinology       Date:  2017-07-01       Impact factor: 4.736

4.  High throughput film dosimetry in homogeneous and heterogeneous media for a small animal irradiator.

Authors:  L Wack; W Ngwa; E Tryggestad; P Tsiamas; R Berbeco; S K Ng; J Hesser; P Zygmanski
Journal:  Phys Med       Date:  2013-03-17       Impact factor: 2.685

5.  A measurement-based X-ray source model characterization for CT dosimetry computations.

Authors:  Mitchell Sommerville; Yannick Poirier; Mauro Tambasco
Journal:  J Appl Clin Med Phys       Date:  2015-11-08       Impact factor: 2.102

6.  Modeling a superficial radiotherapy X-ray source for relative dose calculations.

Authors:  Christopher D Johnstone; Richard LaFontaine; Yannick Poirier; Mauro Tambasco
Journal:  J Appl Clin Med Phys       Date:  2015-05-08       Impact factor: 2.102

7.  Radiation therapy for deep periocular cancer treatments when protons are unavailable: is combining electrons and orthovoltage therapy beneficial?

Authors:  Kevin Martell; Yannick Poirier; Tiezhi Zhang; Alana Hudson; David Spencer; Ferenc Jacso; Richard Hayashi; Robyn Banerjee; Rao Khan; Nathan Wolfe; Jon-Paul Voroney
Journal:  J Radiat Res       Date:  2018-09-01       Impact factor: 2.724

8.  Assessing the deviation from the inverse square law for orthovoltage beams with closed-ended applicators.

Authors:  James Gräfe; Yannick Poirier; Ferenc Jacso; Rao Khan; Hong-Wei Liu; J Eduardo Villarreal-Barajas
Journal:  J Appl Clin Med Phys       Date:  2014-07-08       Impact factor: 2.102

9.  Experimental validation of a kV source model and dose computation method for CBCT imaging in an anthropomorphic phantom.

Authors:  Yannick Poirier; Mauro Tambasco
Journal:  J Appl Clin Med Phys       Date:  2016-07-08       Impact factor: 2.102

  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.