Recent advances in direct catalytic asymmetric transformations under proton-transfer conditions.

Cooperative catalysis has proven to be a particularly powerful strategy for promoting stereoselective organic transformations under mild reaction conditions. The specific interactions between the catalyst components and substrates are precisely orchestrated to elicit high catalytic efficiency and excellent control of the stereochemical course. By harnessing the power of cooperativity, various sets of stereoselective reactions proceed under mild proton-transfer conditions with perfect atom economy. This Minireview summarizes our recent contributions to several C-N and C-C bond-forming reactions in this field and related transformations.