Literature DB >> 21519870

Potential role of AQP1 and VEGF in the development of malignant pleural effusion in mice.

Jing Xuan Zhang1, C M Xie, Z W Zhu, H Y Huang, Z L Zeng.   

Abstract

Recent studies have revealed the important role of aquaporin-1 (AQP1) in tumor cell migration and angiogenesis. However, the function of AQP1 in malignant pleural effusion has not been well characterized. We established a mouse model to examine the role of AQP1 and vascular endothelial growth factor (VEGF) in the development of malignant pleural effusion. We showed that elevated expressions of AQP1 mRNA and VEGF protein were associated with increased volume of malignant pleural effusion. These results suggest that AQP1 and VEGF play important roles in the development of malignant pleural effusion in mice, which may help us find new strategies for the prevention and treatment of malignant pleural effusion.

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Year:  2011        PMID： 21519870     DOI： 10.1007/s12032-011-9960-6

Source DB:  PubMed          Journal:  Med Oncol        ISSN： 1357-0560            Impact factor:   3.064


  27 in total

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Journal:  Chest       Date:  1999-09       Impact factor: 9.410

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Journal:  Lung       Date:  2003       Impact factor: 2.584

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Journal:  Cancer Res       Date:  1993-06-15       Impact factor: 12.701
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  5 in total

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Authors:  Sam W Henderson; Saeed Nourmohammadi; Sunita A Ramesh; Andrea J Yool
Journal:  Biophys Rev       Date:  2022-01-11

Review 2.  Aquaporins in lung health and disease: Emerging roles, regulation, and clinical implications.

Authors:  Ekta Yadav; Niket Yadav; Ariel Hus; Jagjit S Yadav
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3.  Blockade of aquaporin 1 inhibits proliferation, motility, and metastatic potential of mesothelioma in vitro but not in an in vivo model.

Authors:  Sonja Klebe; Kim Griggs; Yuen Cheng; Jack Driml; Douglas W Henderson; Glen Reid
Journal:  Dis Markers       Date:  2015-03-04       Impact factor: 3.434

4.  Intrathrombotic appearances of AQP-1 and AQP-3 in relation to thrombus age in murine deep vein thrombosis model.

Authors:  Mizuho Nosaka; Yuko Ishida; Yumi Kuninaka; Akiko Ishigami; Akira Taruya; Emi Shimada; Yumiko Hashizume; Hiroki Yamamoto; Akihiko Kimura; Fukumi Furukawa; Toshikazu Kondo
Journal:  Int J Legal Med       Date:  2021-01-07       Impact factor: 2.686

5.  Expression of aquaporin1, a water channel protein, in cytoplasm is negatively correlated with prognosis of breast cancer patients.

Authors:  Fengxia Qin; Huikun Zhang; Ying Shao; Xiaoli Liu; Limin Yang; Yong Huang; Li Fu; Feng Gu; Yongjie Ma
Journal:  Oncotarget       Date:  2016-02-16
  5 in total

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