BACKGROUNDS AND AIMS: The IGR2198a_1 and IGR2096a_1 variants of the IBD5 region were found to be associated with Crohn's disease (CD) in the Hungarian population, while IGR2230a_1 does not seem to confer risk for the disease. In the present study, our aim was to investigate the statistical interaction of these three IBD5 polymorphisms with the +49 A/G substitution within the cytotoxic T lymphocyte antigen-4 (CTLA4) gene, detected previously as neutral gene variant in Hungarian IBD patients. METHODS: A total of 305 unrelated subjects with CD and 310 healthy controls were genotyped with PCR-RFLP methods. RESULTS: In contrast with single gene effects, after genotype stratification, the IGR2198a_1 C and IGR2096a_1 T variants were found to confer susceptibility only in subjects with CTLA4 +49 AA genotype (P = 0.008; OR = 1.86 and P = 0.016; OR = 1.74, respectively), for IGR2230a_1 no such effect on disease risk could be demonstrated. CONCLUSION: Analysis of specific genotype combinations unfolded a possible association between the CTLA4 +49 A/G substitution and two of the observed IBD5 variants with respect to disease risk.
BACKGROUNDS AND AIMS: The IGR2198a_1 and IGR2096a_1 variants of the IBD5 region were found to be associated with Crohn's disease (CD) in the Hungarian population, while IGR2230a_1 does not seem to confer risk for the disease. In the present study, our aim was to investigate the statistical interaction of these three IBD5 polymorphisms with the +49 A/G substitution within the cytotoxic T lymphocyte antigen-4 (CTLA4) gene, detected previously as neutral gene variant in Hungarian IBDpatients. METHODS: A total of 305 unrelated subjects with CD and 310 healthy controls were genotyped with PCR-RFLP methods. RESULTS: In contrast with single gene effects, after genotype stratification, the IGR2198a_1 C and IGR2096a_1 T variants were found to confer susceptibility only in subjects with CTLA4 +49 AA genotype (P = 0.008; OR = 1.86 and P = 0.016; OR = 1.74, respectively), for IGR2230a_1 no such effect on disease risk could be demonstrated. CONCLUSION: Analysis of specific genotype combinations unfolded a possible association between the CTLA4+49 A/G substitution and two of the observed IBD5 variants with respect to disease risk.
Authors: Rebecca L Roberts; Richard B Gearry; Jade E Hollis-Moffatt; Allison L Miller; Julia Reid; Victor Abkevich; Kirsten M Timms; Alexander Gutin; Jerry S Lanchbury; Tony R Merriman; Murray L Barclay; Martin A Kennedy Journal: Am J Gastroenterol Date: 2007-09-25 Impact factor: 10.864
Authors: Toshihiko Okazaki; Ming-Hsi Wang; Patricia Rawsthorne; Michael Sargent; Lisa Wu Datta; Yin Yao Shugart; Charles N Bernstein; Steven R Brant Journal: Inflamm Bowel Dis Date: 2008-11 Impact factor: 5.325
Authors: Ivonne Petermann; Claudia Huebner; Brian L Browning; Richard B Gearry; Murray L Barclay; Martin Kennedy; Rebecca Roberts; Andrew N Shelling; Martin Philpott; Dug Yeo Han; Lynnette R Ferguson Journal: Hum Immunol Date: 2009-03-09 Impact factor: 2.850
Authors: H Donner; H Rau; P G Walfish; J Braun; T Siegmund; R Finke; J Herwig; K H Usadel; K Badenhoop Journal: J Clin Endocrinol Metab Date: 1997-01 Impact factor: 5.958
Authors: R K Weersma; P C F Stokkers; A A van Bodegraven; R A van Hogezand; H W Verspaget; D J de Jong; C J van der Woude; B Oldenburg; R K Linskens; E A M Festen; G van der Steege; D W Hommes; J B A Crusius; C Wijmenga; I M Nolte; G Dijkstra Journal: Gut Date: 2008-09-29 Impact factor: 23.059