Literature DB >> 21519405

PPAR-alpha in cutaneous inflammation.

Sandrine Dubrac1, Matthias Schmuth.   

Abstract

Peroxisome proliferator-activated receptor (PPAR)-alpha is a fatty acid activated transcription factors that belongs to the nuclear hormone receptor family. Primarily PPAR-alpha serves as a lipid sensor. While PPAR-alpha controls enzymes from the lipid and glucose metabolism in the liver, heart and muscles, PPAR-alpha is also involved in skin homeostasis. PPAR-alpha controls keratinocyte proliferation/differentiation, contributes to wound healing and regulates skin inflammation. PPAR-alpha activation exerts anti-inflammatory effects in various skin conditions such as irritant and allergic contact dermatitis, atopic dermatitis and UV-induced erythema, rendering investigations into the functions of PPAR-alpha necessary to provide better understandings to treat many inflammatory skin disorders.

Entities:  

Keywords:  PPAR; allergic contact dermatitis; atopic dermatitis; psoriasis; skin barrier

Year:  2011        PMID： 21519405      PMCID： PMC3051849          DOI： 10.4161/derm.3.1.14615

Source DB:  PubMed          Journal:  Dermatoendocrinol        ISSN： 1938-1972


  43 in total

1.  Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation.

Authors:  S Kippenberger; S M Loitsch; M Grundmann-Kollmann; S Simon; T A Dang; K Hardt-Weinelt; R Kaufmann; A Bernd
Journal:  J Invest Dermatol       Date:  2001-12       Impact factor: 8.551

Review 2.  The RXR heterodimers and orphan receptors.

Authors:  D J Mangelsdorf; R M Evans
Journal:  Cell       Date:  1995-12-15       Impact factor: 41.582

3.  Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications.

Authors:  Douglas A Plager; Alexey A Leontovich; Susan A Henke; Mark D P Davis; Marian T McEvoy; Gabriel F Sciallis; Mark R Pittelkow
Journal:  Exp Dermatol       Date:  2007-01       Impact factor: 3.960

4.  Peroxisome proliferator-activated receptor-alpha contributes to the anti-inflammatory activity of glucocorticoids.

Authors:  Salvatore Cuzzocrea; Stefano Bruscoli; Emanuela Mazzon; Concetta Crisafulli; Valerio Donato; Rosanna Di Paola; Enrico Velardi; Emanuela Esposito; Giuseppe Nocentini; Carlo Riccardi
Journal:  Mol Pharmacol       Date:  2007-11-05       Impact factor: 4.436

5.  Protective role of palmitoylethanolamide in contact allergic dermatitis.

Authors:  S Petrosino; L Cristino; M Karsak; E Gaffal; N Ueda; T Tüting; T Bisogno; D De Filippis; A D'Amico; C Saturnino; P Orlando; A Zimmer; T Iuvone; V Di Marzo
Journal:  Allergy       Date:  2009-11-11       Impact factor: 13.146

6.  Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes.

Authors:  M Rivier; I Safonova; P Lebrun; C E Griffiths; G Ailhaud; S Michel
Journal:  J Invest Dermatol       Date:  1998-12       Impact factor: 8.551

7.  Identification of a physiologically relevant endogenous ligand for PPARalpha in liver.

Authors:  Manu V Chakravarthy; Irfan J Lodhi; Li Yin; Raghu R V Malapaka; H Eric Xu; John Turk; Clay F Semenkovich
Journal:  Cell       Date:  2009-07-30       Impact factor: 41.582

Review 8.  Emerging roles of PPARs in inflammation and immunity.

Authors:  Raymond A Daynes; Dallas C Jones
Journal:  Nat Rev Immunol       Date:  2002-10       Impact factor: 53.106

9.  Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis.

Authors:  Delphine Staumont-Sallé; Georges Abboud; Céline Brénuchon; Akira Kanda; Thomas Roumier; Céline Lavogiez; Sébastien Fleury; Patrick Rémy; Jean-Paul Papin; Justine Bertrand-Michel; François Tercé; Bart Staels; Emmanuel Delaporte; Monique Capron; David Dombrowicz
Journal:  J Allergy Clin Immunol       Date:  2008-02-04       Impact factor: 10.793

10.  Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice.

Authors:  L Michalik; B Desvergne; N S Tan; S Basu-Modak; P Escher; J Rieusset; J M Peters; G Kaya; F J Gonzalez; J Zakany; D Metzger; P Chambon; D Duboule; W Wahli
Journal:  J Cell Biol       Date:  2001-08-20       Impact factor: 10.539
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  15 in total

1.  Network analysis reveals dysregulated functional patterns in type II diabetic skin.

Authors:  Chunan Liu; Sudha Ram; Bonnie L Hurwitz
Journal:  Sci Rep       Date:  2022-04-27       Impact factor: 4.996

2.  Mustard vesicants alter expression of the endocannabinoid system in mouse skin.

Authors:  Irene M Wohlman; Gabriella M Composto; Diane E Heck; Ned D Heindel; C Jeffrey Lacey; Christophe D Guillon; Robert P Casillas; Claire R Croutch; Donald R Gerecke; Debra L Laskin; Laurie B Joseph; Jeffrey D Laskin
Journal:  Toxicol Appl Pharmacol       Date:  2016-04-26       Impact factor: 4.219

3.  Homeostatic PPARα Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine.

Authors:  Indumathi Manoharan; Amol Suryawanshi; Yuan Hong; Punithavathi Ranganathan; Arulkumaran Shanmugam; Shamim Ahmad; Daniel Swafford; Balaji Manicassamy; Ganesan Ramesh; Pandelakis A Koni; Muthusamy Thangaraju; Santhakumar Manicassamy
Journal:  J Immunol       Date:  2016-04-25       Impact factor: 5.422

Review 4.  Peripheral gating of pain signals by endogenous lipid mediators.

Authors:  Daniele Piomelli; Oscar Sasso
Journal:  Nat Neurosci       Date:  2014-01-28       Impact factor: 24.884

5.  The transcriptional response of skin to fluorescent light exposure in viviparous (Xiphophorus) and oviparous (Danio, Oryzias) fishes.

Authors:  Mikki Boswell; William Boswell; Yuan Lu; Markita Savage; Zachary Mazurek; Jordan Chang; Jeanot Muster; Ronald Walter
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2017-10-07       Impact factor: 3.228

6.  New insights into the role of peroxisome proliferator-activated receptors in regulating the inflammatory response after tissue injury.

Authors:  Miriam D Neher; Sebastian Weckbach; Markus S Huber-Lang; Philip F Stahel
Journal:  PPAR Res       Date:  2012-02-29       Impact factor: 4.964

7.  Reduced expression of peroxisome proliferator-activated receptor alpha in BAL and blood T cells of non-löfgren's sarcoidosis patients.

Authors:  Muntasir Abo Al Hayja; Anders Eklund; Johan Grunewald; Jan Wahlström
Journal:  J Inflamm (Lond)       Date:  2015-04-09       Impact factor: 4.981

8.  Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and Pathways.

Authors:  Debajyoti Ghosh; Lili Ding; Umasundari Sivaprasad; Esmond Geh; Jocelyn Biagini Myers; Jonathan A Bernstein; Gurjit K Khurana Hershey; Tesfaye B Mersha
Journal:  PLoS One       Date:  2015-12-30       Impact factor: 3.240

9.  The activation of PPARγ by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages.

Authors:  Enrica Flori; Arianna Mastrofrancesco; Daniela Kovacs; Barbara Bellei; Stefania Briganti; Vittoria Maresca; Giorgia Cardinali; Mauro Picardo
Journal:  Sci Rep       Date:  2017-08-23       Impact factor: 4.379

Review 10.  Xenobiotic Receptors and Their Mates in Atopic Dermatitis.

Authors:  Deborah Minzaghi; Petra Pavel; Sandrine Dubrac
Journal:  Int J Mol Sci       Date:  2019-08-29       Impact factor: 5.923
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