Literature DB >> 2151936

Interleukin-1 receptor antagonist: discovery, structure and properties.

W P Arend1.   

Abstract

Interleukin-1 receptor antagonist (IL-1ra) is a recently-described member of the IL-1 family. This unique human protein has 30% amino acid sequence homology to IL-1 beta and binds to human types I and II IL-1 receptors without apparent cellular activation. IL-1ra blocks the in vitro stimulatory effects of IL-1 on thymocytes, fibroblasts, endothelial cells and bone cells. In addition, IL-1ra is a potent inhibitor of the inflammatory effects of IL-1 in vivo. IL-1ra represents the first naturally-occurring cytokine inhibitor and may be important in modulating IL-1 effects in both normal and abnormal physiology.

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Year:  1990        PMID： 2151936     DOI： 10.1016/0955-2235(90)90018-f

Source DB:  PubMed          Journal:  Prog Growth Factor Res        ISSN： 0955-2235


  14 in total

1.  Expression of interleukin-1 (IL-1) ligands system in the most common endometriosis-associated ovarian cancer subtypes.

Authors:  Mamadou Keita; Paul Bessette; Manuella Pelmus; Youssef Ainmelk; Aziz Aris
Journal:  J Ovarian Res       Date:  2010-01-28       Impact factor: 4.234

2.  Interleukin-1β causes fluoxetine resistance in an animal model of epilepsy-associated depression.

Authors:  Eduardo A Pineda; Julie G Hensler; Raman Sankar; Don Shin; Teresa F Burke; Andréy M Mazarati
Journal:  Neurotherapeutics       Date:  2012-04       Impact factor: 7.620

Review 3.  Cytokines, Masticatory Muscle Inflammation, and Pain: an Update.

Authors:  Sara Ayoub; Antoine Berbéri; Mohammad Fayyad-Kazan
Journal:  J Mol Neurosci       Date:  2020-02-01       Impact factor: 3.444

Review 4.  Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis.

Authors:  M H Schiff
Journal:  Ann Rheum Dis       Date:  2000-11       Impact factor: 19.103

Review 5.  Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis.

Authors:  Jan Petrasek; Timea Csak; Michal Ganz; Gyongyi Szabo
Journal:  J Gastroenterol Hepatol       Date:  2013-08       Impact factor: 4.029

6.  Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents.

Authors:  E Somm; P Cettour-Rose; C Asensio; A Charollais; M Klein; C Theander-Carrillo; C E Juge-Aubry; J-M Dayer; M J H Nicklin; P Meda; F Rohner-Jeanrenaud; C A Meier
Journal:  Diabetologia       Date:  2005-12-30       Impact factor: 10.122

7.  Serum levels of interleukin-1 receptor antagonist (IL-1ra) in thyroid cancer patients.

Authors:  Sebastian Niedźwiecki; Tomasz Stepień; Krzysztof Kuzdak; Henryk Stepień; Roman Krupiński; Daniel Seehofer; Nada Rayes; Frank Ulrich
Journal:  Langenbecks Arch Surg       Date:  2007-12-07       Impact factor: 3.445

8.  Endogenous interleukin-10 is required for the defervescence of fever evoked by local lipopolysaccharide-induced and Staphylococcus aureus-induced inflammation in rats.

Authors:  T Cartmell; C Ball; A F Bristow; D Mitchell; S Poole
Journal:  J Physiol       Date:  2003-04-11       Impact factor: 5.182

9.  Is There Inflammatory Synergy in Type II Diabetes Mellitus and Alzheimer's Disease?

Authors:  Lih-Fen Lue; Cassandra Andrade; Marwan Sabbagh; Douglas Walker
Journal:  Int J Alzheimers Dis       Date:  2012-06-21

10.  Interleukin expression after injury and the effects of interleukin-1 receptor antagonist.

Authors:  Connie S Chamberlain; Ellen M Leiferman; Kayt E Frisch; Stacey L Brickson; William L Murphy; Geoffrey S Baer; Ray Vanderby
Journal:  PLoS One       Date:  2013-08-01       Impact factor: 3.240
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