| Literature DB >> 21517126 |
Abstract
An efficient method compatible with Fmoc synthesis for preparing peptide thioesters via an acid-catalyzed tandem "thiol switch" of esters is described first by an intramolecular O-S acyl shift and then by an intermolecular S-S exchange, with concurrent deblocking of side chain protection groups.Entities:
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Year: 2011 PMID： 21517126 DOI： 10.1021/ol2007204
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005