OBJECTIVES: Calcium channel inhibitors have beneficial impact on microcirculation, but beta-blocker effect is controversial. Clinicians still do not agree on beta-blocker combination with other treatments in the management of impaired microcirculation. The aim of the present study was to describe the effects of beta-blocker metoprolol monotherapy and combined with calcium channel inhibitor felodipin on digital microcirculation in primary Raynaud's syndrome. METHODS: We enrolled in this study 46 patients suffering from both hypertension and primary Raynaud's syndrome. Fifteen patients were treated with beta-blocker monotherapy (metoprolol), 13 received combined beta-blocker and calcium channel blocker therapy (felodipin and metoprolol), while 18 patients without any medications served as controls. Measurement of digital microcirculation was carried out with laser Doppler scanner. RESULTS AND CONCLUSIONS: Our investigation concludes that the concurrent administration of beta-blockers with calcium channel inhibitors positively reduces symptoms in patients suffering from Raynaud's syndrome.
OBJECTIVES: Calcium channel inhibitors have beneficial impact on microcirculation, but beta-blocker effect is controversial. Clinicians still do not agree on beta-blocker combination with other treatments in the management of impaired microcirculation. The aim of the present study was to describe the effects of beta-blocker metoprolol monotherapy and combined with calcium channel inhibitor felodipin on digital microcirculation in primary Raynaud's syndrome. METHODS: We enrolled in this study 46 patients suffering from both hypertension and primary Raynaud's syndrome. Fifteen patients were treated with beta-blocker monotherapy (metoprolol), 13 received combined beta-blocker and calcium channel blocker therapy (felodipin and metoprolol), while 18 patients without any medications served as controls. Measurement of digital microcirculation was carried out with laser Doppler scanner. RESULTS AND CONCLUSIONS: Our investigation concludes that the concurrent administration of beta-blockers with calcium channel inhibitors positively reduces symptoms in patients suffering from Raynaud's syndrome.
Authors: Piotr Bienias; Michał Ciurzyński; Bartłomiej Kisiel; Anna Chrzanowska; Katarzyna Ciesielska; Maria Siwicka; Agnieszka Kalińska-Bienias; Marek Saracyn; Monika Lisicka; Joanna Radochońska; Piotr Pruszczyk Journal: Rheumatol Int Date: 2018-11-12 Impact factor: 2.631
Authors: Abhimanyu Amarnani; Perry Wengrofsky; Cindy L Tsui; Pramod Theetha Kariyanna; Naureen Kabani; Louis Salciccioli; Isabel M McFarlane Journal: Am J Med Case Rep Date: 2019-11-05
Authors: Veronika Sebestyén; Gabriella Szűcs; Dénes Páll; Dóra Ujvárosy; Tamás Ötvös; Imre Csige; Tamás Pataki; István Lőrincz; Zoltán Szabó Journal: Rheumatology (Oxford) Date: 2020-03-01 Impact factor: 7.580