| Literature DB >> 21515047 |
Michael Soth1, Sarah Abbot, Allassan Abubakari, Nidhi Arora, Humberto Arzeno, Roland Billedeau, Nolan Dewdney, Kieran Durkin, Sandra Frauchiger, Manjiri Ghate, David M Goldstein, Ronald J Hill, Andreas Kuglstatter, Fujun Li, Brad Loe, Kristen McCaleb, Joel McIntosh, Eva Papp, Jaehyeon Park, Martin Stahl, Man-Ling Sung, Rebecca Suttman, David C Swinney, Paul Weller, Brian Wong, Hasim Zecic, Tobias Gabriel.
Abstract
Learnings from previous Roche p38-selective inhibitors were applied to a new fragment hit, which was optimized to a potent, exquisitely selective preclinical lead with a good pharmacokinetic profile.Entities:
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Year: 2011 PMID： 21515047 DOI： 10.1016/j.bmcl.2011.03.098
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823