BACKGROUND: Because of evidence from genetic linkage and genome-wide association studies, as well as suggested involvement of infection, the major histocompatibility complex (MHC) region on chromosome 6p21.3-22.1 has been implicated in the development of schizophrenia. METHODS: Here, we investigated how gene variants across the MHC region are associated with brain structure in a large ethnically homogenous sample (n = 420), including patients with schizophrenia spectrum disorders and other severe mental illness and healthy control subjects. RESULTS: We demonstrate highly significant associations between common gene markers in the MHC region and cerebral ventricular volume specifically in schizophrenia spectrum patients (uncorrected p values between 1.16 × 10⁻⁴ and 2.00 × 10⁻⁷). One single nucleotide polymorphism, rs2596532, survives Bonferroni correction for multiple testing across all single nucleotide polymorphisms and brain structure measures (adjusted p value 5.59 × 10⁻⁴). CONCLUSIONS: The results indicate that MHC variants are implicated in characteristic brain abnormalities of schizophrenia.
BACKGROUND: Because of evidence from genetic linkage and genome-wide association studies, as well as suggested involvement of infection, the major histocompatibility complex (MHC) region on chromosome 6p21.3-22.1 has been implicated in the development of schizophrenia. METHODS: Here, we investigated how gene variants across the MHC region are associated with brain structure in a large ethnically homogenous sample (n = 420), including patients with schizophrenia spectrum disorders and other severe mental illness and healthy control subjects. RESULTS: We demonstrate highly significant associations between common gene markers in the MHC region and cerebral ventricular volume specifically in schizophrenia spectrum patients (uncorrected p values between 1.16 × 10⁻⁴ and 2.00 × 10⁻⁷). One single nucleotide polymorphism, rs2596532, survives Bonferroni correction for multiple testing across all single nucleotide polymorphisms and brain structure measures (adjusted p value 5.59 × 10⁻⁴). CONCLUSIONS: The results indicate that MHC variants are implicated in characteristic brain abnormalities of schizophrenia.
Authors: Deanna L Kelly; Xin Li; Catherine Kilday; Stephanie Feldman; Sarah Clark; Fang Liu; Robert W Buchanan; Leonardo H Tonelli Journal: Psychiatry Res Date: 2018-09-05 Impact factor: 3.222
Authors: Jiayu Chen; Vince D Calhoun; Dongdong Lin; Nora I Perrone-Bizzozero; Juan R Bustillo; Godfrey D Pearlson; Steven G Potkin; Theo G M van Erp; Fabio Macciardi; Stefan Ehrlich; Beng-Choon Ho; Scott R Sponheim; Lei Wang; Julia M Stephen; Andrew R Mayer; Faith M Hanlon; Rex E Jung; Brett A Clementz; Matcheri S Keshavan; Elliot S Gershon; John A Sweeney; Carol A Tamminga; Ole A Andreassen; Ingrid Agartz; Lars T Westlye; Jing Sui; Yuhui Du; Jessica A Turner; Jingyu Liu Journal: Schizophr Bull Date: 2019-01-01 Impact factor: 9.306
Authors: Yang Zhang; Tianlan Lu; Hao Yan; Yanyan Ruan; Lifang Wang; Dai Zhang; Weihua Yue; Lin Lu Journal: PLoS One Date: 2013-02-21 Impact factor: 3.240
Authors: K V Wirgenes; I E Sønderby; U K Haukvik; M Mattingsdal; M Tesli; L Athanasiu; K Sundet; J I Røssberg; A M Dale; A A Brown; I Agartz; I Melle; S Djurovic; O A Andreassen Journal: Transl Psychiatry Date: 2012-05-08 Impact factor: 6.222