Literature DB >> 21514373

Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex.

J Regino Perez-Polo1, Conor B Reilly, Harriet C Rea.   

Abstract

Exposure to hypoxia and hyperoxia in a rodent model of perinatal ischemia results in delayed cell death and inflammation. Hyperoxia increases oxidative stress that can trigger inflammatory cascades, neutrophil activation, and brain microvascular injury. Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2cys526, PGE2, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.
Copyright © 2011 ISDN. Published by Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21514373      PMCID： PMC3158954          DOI： 10.1016/j.ijdevneu.2011.03.009

Source DB:  PubMed          Journal:  Int J Dev Neurosci        ISSN： 0736-5748            Impact factor:   2.457


  67 in total

Review 1.  Cyclooxygenases: structural, cellular, and molecular biology.

Authors:  W L Smith; D L DeWitt; R M Garavito
Journal:  Annu Rev Biochem       Date:  2000       Impact factor: 23.643

2.  Immature brain injury via peroxynitrite production induced by inducible nitric oxide synthase after hypoxia-ischemia in rats.

Authors:  S Ikeno; N Nagata; S Yoshida; H Takahashi; J Kigawa; N Terakawa
Journal:  J Obstet Gynaecol Res       Date:  2000-06       Impact factor: 1.730

3.  Neuronal and inducible nitric oxide synthase expression and protein nitration in rat cerebellum after oxygen and glucose deprivation.

Authors:  J Rodrigo; D Alonso; A P Fernández; J Serrano; A Richart; J C López; M Santacana; R Martínez-Murillo; M L Bentura; M Ghiglione; L O Uttenthal
Journal:  Brain Res       Date:  2001-08-03       Impact factor: 3.252

4.  Molecular mechanisms of iNOS induction by IL-1 beta and IFN-gamma in rat aortic smooth muscle cells.

Authors:  Xingwu Teng; Hanfang Zhang; Connie Snead; John D Catravas
Journal:  Am J Physiol Cell Physiol       Date:  2002-01       Impact factor: 4.249

5.  Differential NF-kappa B regulation of bcl-x gene expression in hippocampus and basal forebrain in response to hypoxia.

Authors:  J Qiu; M R Grafe; S M Schmura; J N Glasgow; T A Kent; D K Rassin; J R Perez-Polo
Journal:  J Neurosci Res       Date:  2001-05-01       Impact factor: 4.164

6.  A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons.

Authors:  A Almeida; J P Bolaños
Journal:  J Neurochem       Date:  2001-04       Impact factor: 5.372

7.  Time course of expression of three nitric oxide synthase isoforms after transient middle cerebral artery occlusion in rats.

Authors:  M Niwa; S Inao; M Takayasu; T Kawai; Y Kajita; T Nihashi; R Kabeya; T Sugimoto; J Yoshida
Journal:  Neurol Med Chir (Tokyo)       Date:  2001-02       Impact factor: 1.742

8.  Reduction of pathological and behavioral deficits following spinal cord contusion injury with the selective cyclooxygenase-2 inhibitor NS-398.

Authors:  B C Hains; J A Yucra; C E Hulsebosch
Journal:  J Neurotrauma       Date:  2001-04       Impact factor: 5.269

Review 9.  Potential mechanisms of interleukin-1 involvement in cerebral ischaemia.

Authors:  O Touzani; H Boutin; J Chuquet; N Rothwell
Journal:  J Neuroimmunol       Date:  1999-12       Impact factor: 3.478

10.  Electrochemical monitoring of superoxide anion production and cerebral blood flow: effect of interleukin-1 beta pretreatment in a model of focal ischemia and reperfusion.

Authors:  R H Fabian; J R Perez-Polo; T A Kent
Journal:  J Neurosci Res       Date:  2000-06-15       Impact factor: 4.164
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  4 in total

1.  Decreased VEGF expression and microvascular density, but increased HIF-1 and 2α accumulation and EPO expression in chronic moderate hyperoxia in the mouse brain.

Authors:  Girriso F Benderro; Xiaoyan Sun; Youzhi Kuang; Joseph C Lamanna
Journal:  Brain Res       Date:  2012-07-20       Impact factor: 3.252

2.  Prostaglandin E2 differentially modulates the central control of eupnoea, sighs and gasping in mice.

Authors:  Henner Koch; Cali Caughie; Frank P Elsen; Atsushi Doi; Alfredo J Garcia; Sebastien Zanella; Jan-Marino Ramirez
Journal:  J Physiol       Date:  2014-11-03       Impact factor: 5.182

3.  Regional Differences in the Neuronal Expression of Cyclooxygenase-2 (COX-2) in the Newborn Pig Brain.

Authors:  Orsolya Oláh; István Németh; Valéria Tóth-Szűki; Ferenc Bari; Ferenc Domoki
Journal:  Acta Histochem Cytochem       Date:  2012-05-15       Impact factor: 1.938

4.  Monitoring of cerebral blood flow during hypoxia-ischemia and resuscitation in the neonatal rat using laser speckle imaging.

Authors:  Thomas Wood; Elisa Smit; Elke Maes; Damjan Osredkar; Mari Falck; Maja Elstad; Marianne Thoresen
Journal:  Physiol Rep       Date:  2016-04-13
  4 in total

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