INTRODUCTION: Quality of life is an important patient-oriented measure in COPD. The Clinical COPD Questionnaire (CCQ) is a validated instrument for estimating quality of life. The impact of different factors on the CCQ-score remains an understudied area. The aim of this study was to investigate the association of co-morbidity and body mass index with quality of life measured by CCQ. METHODS: A patient questionnaire including the CCQ and a review of records were used. A total of 1548 COPD patients in central Sweden were randomly selected. Complete data were collected for 919 patients, 639 from primary health care and 280 from hospital clinics. Multiple linear regression with adjustment for sex, age, level of education, smoking habits and level of care was performed. Subanalyses included additional adjustment for lung function in the subgroup (n = 475) where spirometry data were available. RESULTS: Higher mean CCQ score indicating lower quality of life was statistically significant and independently associated with heart disease (adjusted regression coefficient (95%CI) 0.26; 0.06 to 0.47), depression (0.50; 0.23 to 0.76) and underweight (0.58; 0.29 to 0.87). Depression and underweight were associated with higher scores in all CCQ subdomains. Further adjustment for lung function in the subgroup with this measure resulted in statistically significant and independent associations with CCQ for heart disease, depression, obesity and underweight. CONCLUSION: The CCQ identified that heart disease, depression and underweight are independently associated with lower health-related quality of life in COPD.
INTRODUCTION: Quality of life is an important patient-oriented measure in COPD. The Clinical COPD Questionnaire (CCQ) is a validated instrument for estimating quality of life. The impact of different factors on the CCQ-score remains an understudied area. The aim of this study was to investigate the association of co-morbidity and body mass index with quality of life measured by CCQ. METHODS: A patient questionnaire including the CCQ and a review of records were used. A total of 1548 COPD patients in central Sweden were randomly selected. Complete data were collected for 919 patients, 639 from primary health care and 280 from hospital clinics. Multiple linear regression with adjustment for sex, age, level of education, smoking habits and level of care was performed. Subanalyses included additional adjustment for lung function in the subgroup (n = 475) where spirometry data were available. RESULTS: Higher mean CCQ score indicating lower quality of life was statistically significant and independently associated with heart disease (adjusted regression coefficient (95%CI) 0.26; 0.06 to 0.47), depression (0.50; 0.23 to 0.76) and underweight (0.58; 0.29 to 0.87). Depression and underweight were associated with higher scores in all CCQ subdomains. Further adjustment for lung function in the subgroup with this measure resulted in statistically significant and independent associations with CCQ for heart disease, depression, obesity and underweight. CONCLUSION: The CCQ identified that heart disease, depression and underweight are independently associated with lower health-related quality of life in COPD.
Authors: François Maltais; Marc Decramer; Richard Casaburi; Esther Barreiro; Yan Burelle; Richard Debigaré; P N Richard Dekhuijzen; Frits Franssen; Ghislaine Gayan-Ramirez; Joaquim Gea; Harry R Gosker; Rik Gosselink; Maurice Hayot; Sabah N A Hussain; Wim Janssens; Micheal I Polkey; Josep Roca; Didier Saey; Annemie M W J Schols; Martijn A Spruit; Michael Steiner; Tanja Taivassalo; Thierry Troosters; Ioannis Vogiatzis; Peter D Wagner Journal: Am J Respir Crit Care Med Date: 2014-05-01 Impact factor: 21.405
Authors: Nirupama Putcha; Meilan K Han; Carlos H Martinez; Marilyn G Foreman; Antonio R Anzueto; Richard Casaburi; Michael H Cho; Nicola A Hanania; Craig P Hersh; Gregory L Kinney; Barry J Make; Robert M Steiner; Sharon M Lutz; Byron M Thomashow; Andre A Williams; Surya P Bhatt; Terri H Beaty; Russell P Bowler; Joe W Ramsdell; Jeffrey L Curtis; Douglas Everett; John E Hokanson; David A Lynch; E Rand Sutherland; Edwin K Silverman; James D Crapo; Robert A Wise; Elizabeth A Regan; Nadia N Hansel Journal: Chronic Obstr Pulm Dis Date: 2014
Authors: Cristina Esquinas; Maria A Ramon; Alexa Nuñez; Jesús Molina; José A Quintano; Miguel Roman-Rodríguez; Karlos Naberan; Carl Llor; Carlos Roncero; Marc Miravitlles; Miriam Barrecheguren Journal: Qual Life Res Date: 2019-10-31 Impact factor: 4.147
Authors: Marc Miravitlles; David Price; Klaus F Rabe; Hendrik Schmidt; Norbert Metzdorf; Bartolome Celli Journal: Int J Chron Obstruct Pulmon Dis Date: 2015-03-16