Literature DB >> 21512693

Structure-activity studies of the pelorusides: new congeners and semi-synthetic analogues.

A Jonathan Singh1, Mina Razzak, Paul Teesdale-Spittle, Thomas N Gaitanos, Anja Wilmes, Ian Paterson, Jonathan M Goodman, John H Miller, Peter T Northcote.   

Abstract

Two new peloruside congeners (3 and 4) were isolated from wild and aquacultured collections of the New Zealand marine sponge Mycale hentscheli. Small-scale reactions on peloruside A (1) have been performed, which along with the isolation of 3 and 4, give further insight into the bioactive pharmacophore of 1.

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Year:  2011        PMID： 21512693     DOI： 10.1039/c0ob01127d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  8 in total

Review 1.  Conformation-activity relationships of polyketide natural products.

Authors:  Erik M Larsen; Matthew R Wilson; Richard E Taylor
Journal:  Nat Prod Rep       Date:  2015-08       Impact factor: 13.423

Review 2.  Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

Authors:  Carlo Ballatore; Kurt R Brunden; Donna M Huryn; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith
Journal:  J Med Chem       Date:  2012-09-28       Impact factor: 7.446

3.  Peloruside A, a microtubule-stabilizing agent, induces aneuploidy in ovarian cancer cells.

Authors:  Ariane Chan; A Jonathan Singh; Peter T Northcote; John H Miller
Journal:  Invest New Drugs       Date:  2016-05-07       Impact factor: 3.850

4.  Rapid access to conformational analogues of (+)-peloruside A.

Authors:  Zhiming Zhao; Richard E Taylor
Journal:  Org Lett       Date:  2012-01-11       Impact factor: 6.005

Review 5.  Natural products: a continuing source of novel drug leads.

Authors:  Gordon M Cragg; David J Newman
Journal:  Biochim Biophys Acta       Date:  2013-02-18

Review 6.  Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria.

Authors:  Amr El-Demerdash; Mohamed A Tammam; Atanas G Atanasov; John N A Hooper; Ali Al-Mourabit; Anake Kijjoa
Journal:  Mar Drugs       Date:  2018-06-18       Impact factor: 5.118

7.  Synthesis of a simplified triazole analogue of pateamine A.

Authors:  A Hemi Cumming; Sarah L Brown; Xu Tao; Claire Cuyamendous; Jessica J Field; John H Miller; Joanne E Harvey; Paul H Teesdale-Spittle
Journal:  Org Biomol Chem       Date:  2016-05-16       Impact factor: 3.876

Review 8.  Mitotic Poisons in Research and Medicine.

Authors:  Jan Škubník; Michal Jurášek; Tomáš Ruml; Silvie Rimpelová
Journal:  Molecules       Date:  2020-10-12       Impact factor: 4.411
  8 in total

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