Literature DB >> 21512418

Homocysteine effects on brain volumes mapped in 732 elderly individuals.

Priya Rajagopalan1, Xue Hua, Arthur W Toga, Clifford R Jack, Michael W Weiner, Paul M Thompson.   

Abstract

Elevated homocysteine levels are a known risk factor for Alzheimer's disease and vascular disorders. Here we applied tensor-based morphometry to brain magnetic resonance imaging scans of 732 elderly individuals from the Alzheimer's Disease Neuroimaging Initiative study, to determine associations between homocysteine and brain atrophy. Those with higher homocysteine levels showed greater frontal, parietal, and occipital white matter atrophy in the entire cohort, irrespective of diagnosis, age, or sex. This association was also found when considering mild cognitive impairment individuals separately. Vitamin B supplements, such as folate, may help prevent homocysteine-related atrophy in Alzheimer's disease by possibly reducing homocysteine levels. These atrophy profiles may, in the future, offer a potential biomarker to gauge the efficacy of interventions using dietary folate supplementation.

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Year:  2011        PMID： 21512418      PMCID： PMC3192851          DOI： 10.1097/WNR.0b013e328346bf85

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  17 in total

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3.  Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects.

Authors:  Xue Hua; Alex D Leow; Neelroop Parikshak; Suh Lee; Ming-Chang Chiang; Arthur W Toga; Clifford R Jack; Michael W Weiner; Paul M Thompson
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4.  Multimodality image registration by maximization of mutual information.

Authors:  F Maes; A Collignon; D Vandermeulen; G Marchal; P Suetens
Journal:  IEEE Trans Med Imaging       Date:  1997-04       Impact factor: 10.048

Review 5.  Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders.

Authors:  Mark P Mattson; Thomas B Shea
Journal:  Trends Neurosci       Date:  2003-03       Impact factor: 13.837

6.  Ways toward an early diagnosis in Alzheimer's disease: the Alzheimer's Disease Neuroimaging Initiative (ADNI).

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Review 7.  Homocysteine and brain atrophy.

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Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2005-09       Impact factor: 5.067

8.  Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease.

Authors:  R Clarke; A D Smith; K A Jobst; H Refsum; L Sutton; P M Ueland
Journal:  Arch Neurol       Date:  1998-11

Review 9.  Homocysteine and Alzheimer's disease.

Authors:  Martha Savaria Morris
Journal:  Lancet Neurol       Date:  2003-07       Impact factor: 44.182

10.  Plasma total homocysteine levels and cranial magnetic resonance imaging findings in elderly persons: the Cardiovascular Health Study.

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  29 in total

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Journal:  J Alzheimers Dis       Date:  2016       Impact factor: 4.472

Review 4.  Functional brain connectivity using fMRI in aging and Alzheimer's disease.

Authors:  Emily L Dennis; Paul M Thompson
Journal:  Neuropsychol Rev       Date:  2014-02-23       Impact factor: 7.444

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Review 6.  Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.

Authors:  Michael W Weiner; Dallas P Veitch; Paul S Aisen; Laurel A Beckett; Nigel J Cairns; Robert C Green; Danielle Harvey; Clifford R Jack; William Jagust; John C Morris; Ronald C Petersen; Andrew J Saykin; Leslie M Shaw; Arthur W Toga; John Q Trojanowski
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Review 7.  2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.

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Journal:  Alzheimers Dement       Date:  2015-06       Impact factor: 21.566

8.  Higher homocysteine associated with thinner cortical gray matter in 803 participants from the Alzheimer's Disease Neuroimaging Initiative.

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Journal:  J Mol Neurosci       Date:  2012-07-29       Impact factor: 3.444
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