Ahmet Celik1. 1. Department of Cardiology, Elazig Education and Research Hospital, Elazig, Turkey. ahmetcelik39@hotmail.com
Abstract
AIM: The increase of tenascin-C levels after myocardial infarction has been demonstrated by previous studies. The relationship between tenascin-C and the grade of stenosis in the infarct-related coronary artery was indeterminate. The aim of this study was to evaluate the relationship between tenascin-C levels and total occlusion after acute myocardial infarction. METHOD: Fifty-nine patients with subacute anterior myocardial infarction were divided into two groups according to their having a totally or subtotally occluded left anterior desending artery. Plasma tenascin-C, troponin I, CK-MB, uric acid, mean platelet volume, and lipid profile levels were also measured. RESULTS: The history of the smoking rate, hypertension and diabetes mellitus were similar in both groups. Hemoglobin, mean platelet volume, serum creatinine, CK-MB, troponin I, serum lipid profile and uric acid levels were similar in the two groups. The CRP and tenascin-C levels were significantly higher in the total occlusion group. Tenascin-C levels were highest in patients with proximal LAD total occlusion and lowest in patients with subtotal LAD occlusion. The tenascin-C levels were correlated with the grade of stenosis (r = 0.602, p < 0.001). CONCLUSION: This study demonstrates that higher tenascin-C levels were related with the total occlusion and inflammation after MI.
AIM: The increase of tenascin-C levels after myocardial infarction has been demonstrated by previous studies. The relationship between tenascin-C and the grade of stenosis in the infarct-related coronary artery was indeterminate. The aim of this study was to evaluate the relationship between tenascin-C levels and total occlusion after acute myocardial infarction. METHOD: Fifty-nine patients with subacute anterior myocardial infarction were divided into two groups according to their having a totally or subtotally occluded left anterior desending artery. Plasma tenascin-C, troponin I, CK-MB, uric acid, mean platelet volume, and lipid profile levels were also measured. RESULTS: The history of the smoking rate, hypertension and diabetes mellitus were similar in both groups. Hemoglobin, mean platelet volume, serum creatinine, CK-MB, troponin I, serum lipid profile and uric acid levels were similar in the two groups. The CRP and tenascin-C levels were significantly higher in the total occlusion group. Tenascin-C levels were highest in patients with proximal LAD total occlusion and lowest in patients with subtotal LAD occlusion. The tenascin-C levels were correlated with the grade of stenosis (r = 0.602, p < 0.001). CONCLUSION: This study demonstrates that higher tenascin-C levels were related with the total occlusion and inflammation after MI.
Authors: Ahmet Celik; Nihat Kalay; Omer Sahin; Mustafa Duran; Hasan Korkmaz; Mehmet Ali Kobat; Ertugrul Kurtoglu; Ali Dogan; Sabahattin Muhtaroglu; Oguzhan Baran; Mehmet Tugrul Inanc; Ibrahim Ozdogru; Abdurrahman Oguzhan; Ramazan Topsakal Journal: J Clin Med Res Date: 2012-01-17
Authors: Ahmet Celik; Ozgur Gunebakmaz; Oguzhan Baran; Orhan Dogdu; Deniz Elcik; Mehmet Ali Kobat; Mehmet Balin; Kenan Erdem; Suleyman Aydin; Ibrahim Ozdogru; Ramazan Topsakal Journal: Med Princ Pract Date: 2012-08-08 Impact factor: 1.927