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Literature DB >> 21512225

Ganodermasides C and D, two new anti-aging ergosterols from spores of the medicinal mushroom Ganoderma lucidum.

Yufang Weng¹, Jun Lu, Lan Xiang, Akira Matsuura, Yang Zhang, Qianming Huang, Jianhua Qi.

Abstract

Two new anti-aging compounds, ganodermasides C and D, were isolated and their structures elucidated. They are novel ergosterols possessing a 4,6,8(14),22-tetraene-3-one unit with unique hydroxylation at C-9. Both of them significantly extended the replicative lifespan of the K6001 yeast strain. Ganodermasides C and D regulated the expression of the gene for UTH1 to prolong the replicative lifespan of yeast.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Ergosterol

Year: 2011 PMID： 21512225 DOI： 10.1271/bbb.100918

Source DB: PubMed Journal: Biosci Biotechnol Biochem ISSN： 0916-8451 Impact factor: 2.043

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Cited

7 in total

1. Effects of Ganoderma Lucidum shell-broken spore on oxidative stress of the rabbit urinary bladder using an in vivo model of ischemia/reperfusion.

Authors: Robert M Levin; Li Xia; Wu Wei; Catherine Schuler; Robert E Leggett; Alpha D-Y Lin
Journal: Mol Cell Biochem Date: 2017-05-08 Impact factor: 3.396

2. A Steroidal Saponin from Ophiopogon japonicus Extends the Lifespan of Yeast via the Pathway Involved in SOD and UTH1.

Authors: Kaiyue Sun; Shining Cao; Liang Pei; Akira Matsuura; Lan Xiang; Jianhua Qi
Journal: Int J Mol Sci Date: 2013-02-25 Impact factor: 5.923

3. Cordyceps militaris extract protects human dermal fibroblasts against oxidative stress-induced apoptosis and premature senescence.

Authors: Jun Myoung Park; Jong Seok Lee; Ki Rim Lee; Suk-Jin Ha; Eock Kee Hong
Journal: Nutrients Date: 2014-09-16 Impact factor: 5.717

Ganodermasides C and D, two new anti-aging ergosterols from spores of the medicinal mushroom Ganoderma lucidum.

1. Effects of Ganoderma Lucidum shell-broken spore on oxidative stress of the rabbit urinary bladder using an in vivo model of ischemia/reperfusion.

2. A Steroidal Saponin from Ophiopogon japonicus Extends the Lifespan of Yeast via the Pathway Involved in SOD and UTH1.

3. Cordyceps militaris extract protects human dermal fibroblasts against oxidative stress-induced apoptosis and premature senescence.

Review 4. Structure and Biological Activity of Ergostane-Type Steroids from Fungi.

5. Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11.

6. Parishin from Gastrodia elata Extends the Lifespan of Yeast via Regulation of Sir2/Uth1/TOR Signaling Pathway.

7. Antiaging of Cucurbitane Glycosides from Fruits of Momordica charantia L.