BACKGROUND AND PURPOSE: Only a few reports have dealt with the association of antioxidant vitamin intakes with mortality or morbidity from cardiovascular disease in Asia. We investigated the relation of dietary vitamins A, E, and C intake with mortality from cardiovascular disease for Japanese men and women. METHODS: The subjects were 23,119 men and 35 611 women aged 40 to 79 years without a history of cardiovascular disease or cancer who responded to the food frequency questionnaire as part of the Japan Collaborative Cohort Study for Cancer Risk (JACC) Study. They were followed up for a median period of 16.5 years. Hazard ratios were calculated per quintile of dietary vitamins A, E, and C intake by using Cox proportional hazard model. RESULTS: During the 859,962 person-year follow-up, there were 2690 deaths (1343 men and 1347 women) from cardiovascular disease, comprising 1227 (607 men and 620 women) from stroke and 557 (311 men and 246 women) from coronary heart disease. The multivariable hazard ratios (95% CI) associated with the highest versus lowest quintiles of vitamin C intake were 0.70 (0.54 to 0.92) for total stroke, 0.63 (0.41 to 0.97) for coronary heart disease, and 0.79 (0.66 to 0.94) for total cardiovascular disease for women, but the inverse associations observed were weak and did not reach statistical significance for men. No significant association was observed between vitamins A or E intake and risk of mortality for either men or women. CONCLUSIONS: Vitamin C intake is inversely associated with mortality from cardiovascular disease for Japanese women.
BACKGROUND AND PURPOSE: Only a few reports have dealt with the association of antioxidant vitamin intakes with mortality or morbidity from cardiovascular disease in Asia. We investigated the relation of dietary vitamins A, E, and C intake with mortality from cardiovascular disease for Japanese men and women. METHODS: The subjects were 23,119 men and 35 611 women aged 40 to 79 years without a history of cardiovascular disease or cancer who responded to the food frequency questionnaire as part of the Japan Collaborative Cohort Study for Cancer Risk (JACC) Study. They were followed up for a median period of 16.5 years. Hazard ratios were calculated per quintile of dietary vitamins A, E, and C intake by using Cox proportional hazard model. RESULTS: During the 859,962 person-year follow-up, there were 2690 deaths (1343 men and 1347 women) from cardiovascular disease, comprising 1227 (607 men and 620 women) from stroke and 557 (311 men and 246 women) from coronary heart disease. The multivariable hazard ratios (95% CI) associated with the highest versus lowest quintiles of vitamin C intake were 0.70 (0.54 to 0.92) for total stroke, 0.63 (0.41 to 0.97) for coronary heart disease, and 0.79 (0.66 to 0.94) for total cardiovascular disease for women, but the inverse associations observed were weak and did not reach statistical significance for men. No significant association was observed between vitamins A or E intake and risk of mortality for either men or women. CONCLUSIONS:Vitamin C intake is inversely associated with mortality from cardiovascular disease for Japanese women.
Authors: Dalton Bertolim Précoma; Gláucia Maria Moraes de Oliveira; Antonio Felipe Simão; Oscar Pereira Dutra; Otávio Rizzi Coelho; Maria Cristina de Oliveira Izar; Rui Manuel Dos Santos Póvoa; Isabela de Carlos Back Giuliano; Aristóteles Comte de Alencar Filho; Carlos Alberto Machado; Carlos Scherr; Francisco Antonio Helfenstein Fonseca; Raul Dias Dos Santos Filho; Tales de Carvalho; Álvaro Avezum; Roberto Esporcatte; Bruno Ramos Nascimento; David de Pádua Brasil; Gabriel Porto Soares; Paolo Blanco Villela; Roberto Muniz Ferreira; Wolney de Andrade Martins; Andrei C Sposito; Bruno Halpern; José Francisco Kerr Saraiva; Luiz Sergio Fernandes Carvalho; Marcos Antônio Tambascia; Otávio Rizzi Coelho-Filho; Adriana Bertolami; Harry Correa Filho; Hermes Toros Xavier; José Rocha Faria-Neto; Marcelo Chiara Bertolami; Viviane Zorzanelli Rocha Giraldez; Andrea Araújo Brandão; Audes Diógenes de Magalhães Feitosa; Celso Amodeo; Dilma do Socorro Moraes de Souza; Eduardo Costa Duarte Barbosa; Marcus Vinícius Bolívar Malachias; Weimar Kunz Sebba Barroso de Souza; Fernando Augusto Alves da Costa; Ivan Romero Rivera; Lucia Campos Pellanda; Maria Alayde Mendonça da Silva; Aloyzio Cechella Achutti; André Ribeiro Langowiski; Carla Janice Baister Lantieri; Jaqueline Ribeiro Scholz; Silvia Maria Cury Ismael; José Carlos Aidar Ayoub; Luiz César Nazário Scala; Mario Fritsch Neves; Paulo Cesar Brandão Veiga Jardim; Sandra Cristina Pereira Costa Fuchs; Thiago de Souza Veiga Jardim; Emilio Hideyuki Moriguchi; Jamil Cherem Schneider; Marcelo Heitor Vieira Assad; Sergio Emanuel Kaiser; Ana Maria Lottenberg; Carlos Daniel Magnoni; Marcio Hiroshi Miname; Roberta Soares Lara; Artur Haddad Herdy; Cláudio Gil Soares de Araújo; Mauricio Milani; Miguel Morita Fernandes da Silva; Ricardo Stein; Fernando Antonio Lucchese; Fernando Nobre; Hermilo Borba Griz; Lucélia Batista Neves Cunha Magalhães; Mario Henrique Elesbão de Borba; Mauro Ricardo Nunes Pontes; Ricardo Mourilhe-Rocha Journal: Arq Bras Cardiol Date: 2019-11-04 Impact factor: 2.000
Authors: N Mohammadifard; M Talaei; M Sadeghi; S Oveisegharan; J Golshahi; A Esmaillzadeh; N Sarrafzadegan Journal: Eur J Clin Nutr Date: 2016-10-19 Impact factor: 4.016