Literature DB >> 21511470

Dual function inhibitors of relevance to chronic obstructive pulmonary disease.

Dengfeng Dou1, Guijia He, Kevin R Alliston, William C Groutas.   

Abstract

The general strategy and rationale underlying the design of COPD therapeutics that possess protease inhibitory activity and are also capable of releasing a species that attenuates inflammation by inhibiting caspase-1, are described. The synthesis and in vitro biochemical evaluation of a dual function molecule that sequentially inhibits HNE and caspase-1 in a time-dependent manner is reported.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 21511470      PMCID： PMC3147253          DOI： 10.1016/j.bmcl.2010.12.033

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  28 in total

1.  Apoptosis and emphysema: the missing link.

Authors:  Rubin M Tuder; Irina Petrache; Jack A Elias; Norbert F Voelkel; Peter M Henson
Journal:  Am J Respir Cell Mol Biol       Date:  2003-05       Impact factor: 6.914

Review 2.  Proteases and lung injury.

Authors:  Theo J Moraes; Chung-Wai Chow; Gregory P Downey
Journal:  Crit Care Med       Date:  2003-04       Impact factor: 7.598

Review 3.  The behavior and significance of slow-binding enzyme inhibitors.

Authors:  J F Morrison; C T Walsh
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1988

4.  P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme.

Authors:  R E Dolle; D Hoyer; C V Prasad; S J Schmidt; C T Helaszek; R E Miller; M A Ator
Journal:  J Med Chem       Date:  1994-03-04       Impact factor: 7.446

5.  Alveolar wall apoptosis causes lung destruction and emphysematous changes.

Authors:  Kazutetsu Aoshiba; Naoko Yokohori; Atsushi Nagai
Journal:  Am J Respir Cell Mol Biol       Date:  2003-05       Impact factor: 6.914

6.  Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold.

Authors:  W C Groutas; R Kuang; R Venkataraman; J B Epp; S Ruan; O Prakash
Journal:  Biochemistry       Date:  1997-04-22       Impact factor: 3.162

7.  New mechanism-based inactivators of trypsin-like proteinases. Selective inactivation of urokinase by functionalized cyclopeptides incorporating a sulfoniomethyl-substituted m-aminobenzoic acid residue.

Authors:  M Wakselman; J Xie; J P Mazaleyrat; N Boggetto; A C Vilain; J J Montagne; M Reboud-Ravaux
Journal:  J Med Chem       Date:  1993-05-28       Impact factor: 7.446

Review 8.  Burden and pathogenesis of chronic obstructive pulmonary disease.

Authors:  Robert A Stockley; David Mannino; Peter J Barnes
Journal:  Proc Am Thorac Soc       Date:  2009-09-15

Review 9.  Molecular pathogenesis of emphysema.

Authors:  Laimute Taraseviciene-Stewart; Norbert F Voelkel
Journal:  J Clin Invest       Date:  2008-02       Impact factor: 14.808

10.  X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor.

Authors:  W Bode; A Z Wei; R Huber; E Meyer; J Travis; S Neumann
Journal:  EMBO J       Date:  1986-10       Impact factor: 11.598
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  1 in total

1.  Effects of Glutathione S-Transferase Gene Polymorphisms and Antioxidant Capacity per Unit Albumin on the Pathogenesis of Chronic Obstructive Pulmonary Disease.

Authors:  Tinghui Cao; Naijin Xu; Zhen Wang; Hui Liu
Journal:  Oxid Med Cell Longev       Date:  2017-08-30       Impact factor: 6.543
  1 in total

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